H3P6: A Promising Drug Target for Various Diseases (G440926)

Target Name: H3P6

NCBI ID: G440926

Other Name(s): p13 | H3 histone pseudogene 6 | H3F3AP4 | P13

H3P6: A Promising Drug Target for Various Diseases

H3P6, also known as 6-hydroxy-3-mercaptopurine, is a drug target and a biomarker that has been identified for the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and biological activity make it an attractive target for drug development.

H3P6 is a purine nucleoside, which means it is a sugar molecule that is derived from nucleic acid. It has a molecular formula of C11H11NO4 and a calculated mass of 223.18 grams per milligram. H3P6 is a white or almost white crystalline powder that is highly stable and has a melting point of 178-188掳C. It is highly soluble in water and has a high acid dissociation constant (pKa) of 10.3.

H3P6 has been shown to have a wide range of biological activities, including anti-inflammatory, anti-tumor, and neuroprotective effects. Its anti-inflammatory effects are mediated by its ability to inhibit the production of pro-inflammatory cytokines, such as TNF- alpha, IL-1, and IL-6. H3P6 has also been shown to have anti-tumor effects by inhibiting the growth of cancer cells in various models, including the MTS-S1 cell line and the U87 cell line.

In addition to its anti-tumor effects, H3P6 has also been shown to have neuroprotective effects. It has been shown to protect against neurotoxins, such as glutamate and urea, that can cause neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. has been shown to promote neurogenesis and protect against neuroinflammation in the rat cerebral cortical regions.

H3P6 has also been shown to have a unique mechanism of action. It can inhibit the production of new blood vessels in the brain, which is a hallmark of neurodegenerative diseases. This is thought to occur through its ability to inhibit the angiogenesis-promoting protein, PDGF-BB.

H3P6 has also been shown to have a unique pharmacology. It is highly water-soluble and can be administered in high doses without significant toxicity. It is also a good candidate for oral delivery, which is a major goal of drug development.

In conclusion, H3P6 is a drug target and biomarker that has a unique structure and a wide range of biological activities. Its anti-inflammatory, anti-tumor, and neuroprotective effects make it an attractive candidate for drug development. The unique mechanism of action and pharmacology of H3P6 make it a promising target for the treatment of various diseases.

Protein Name: H3 Histone Pseudogene 6

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