HADH: A Drug Target / Disease Biomarker (G3033)

Target Name: HADH

NCBI ID: G3033

HADH: A Drug Target / Disease Biomarker

HADH, or hypoxic-adaptive domain, is a protein that is expressed in the brain and plays a critical role in the regulation of oxygenation and metabolism. It is composed of multiple domains, including an N-terminus, a T-terminus, and a middle domain that contains the protein's catalytic active site and subcellular localization information.

HADH is a key regulator of oxygenation in the brain, as it is responsible for the uptake and distribution of oxygen from the bloodstream to the brain cells. It does this by interacting with the blood vessels, which are essential for delivering oxygen and nutrients to the brain. In addition, HADH is involved in the regulation of metabolism and energy homeostasis in the brain, which are critical for maintaining the brain's functional integrity and health.

HADH is a protein that can be targeted by small molecules, which may be used to treat various neurological and psychiatric disorders. For example, some studies have suggested that HADH may be a potential drug target for the treatment of Alzheimer's disease, which is characterized by the progressive accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain.

Research has also suggested that HADH may be a potential biomarker for the early detection of Alzheimer's disease. By analyzing the levels of HADH in brain tissue, researchers may be able to identify individuals who are at risk for developing Alzheimer's disease, which could allow for the development of earlier interventions and potential therapies.

In addition to its potential therapeutic applications, HADH has also been studied for its potential diagnostic applications. The hypoxic-adaptive domain of HADH is highly conserved across species, which suggests that it may be a useful biomarker for the diagnosis of certain neurological disorders. For example, some studies have suggested that HADH may be a potential biomarker for the diagnosis of neurodegenerative diseases, such as Parkinson's disease and Huntington's disease.

Overall, HADH is a protein that is critical for the regulation of oxygenation and metabolism in the brain. Its study has suggested that it may be a potential drug target and biomarker for the treatment and diagnosis of various neurological and psychiatric disorders. Further research is needed to fully understand the role of HADH in brain function and to develop effective therapies and diagnostics based on its properties.

Protein Name: Hydroxyacyl-CoA Dehydrogenase

Functions: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity)

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