H2B Plays A Key Role in Cell Growth, Apoptosis and Autophagy, Making It A Potential Drug Target
H2B Plays A Key Role in Cell Growth, Apoptosis and Autophagy, Making It A Potential Drug Target
Histone H2B is a key protein that plays a critical role in the regulation of gene expression and cell behavior. H2B is a type 1 transmembrane protein that consists of four histone domains: H2A, H2B, H3A, and H3B. H2B is often targeted by drugs because of its unique structure and the impact it has on cellular processes.
H2BC8 is a specific isoform of the histone H2B protein that is expressed in various tissues and cell types. It is characterized by the presence of one or more of the following histone modifications: 纬-tubulin, calbindin, and/or polyglutamylated domains. H2BC8 is a potential drug target because of its involvement in various cellular processes, including cell growth, apoptosis, and autophagy.
One of the key functions of H2B is its role in regulating microtubule dynamics and stability. Microtubules are dynamic protein structures that play a critical role in the transport of cellular organelles and vesicles within the cytosome. H2B is known to interact with microtubules and regulate their stability , which has implications for the regulation of cellular processes such as cell division, migration, and invasion.
H2B is also involved in the regulation of cell apoptosis, which is the process by which cells die and are removed from the body. H2B has been shown to play a positive role in the regulation of apoptosis, and it is thought to influence the survival and death of various cell types.
In addition to its role in regulating microtubule dynamics and cell apoptosis, H2B is also involved in the regulation of cellular signaling pathways. H2B has been shown to interact with various signaling molecules, including TGF-β, NF-kappa-B, and MAPKs. It is also a known target for several drugs, including taxanes and protective agents.
H2BC8 is a specific isoform of the histone H2B protein that is expressed in various tissues and cell types. It is characterized by the presence of one or more of the following histone modifications: 纬-tubulin, calbindin, and/or polyglutamylated domains. H2BC8 is a potential drug target because of its involvement in various cellular processes, including cell growth, apoptosis, and autophagy.
In conclusion, H2BC8 is a unique and highly expressed protein that plays a critical role in the regulation of various cellular processes. Its involvement in the regulation of microtubule dynamics, cell apoptosis, and cellular signaling pathways makes it a potential drug target. Further research is needed to fully understand the mechanisms of H2BC8 and its potential as a drug.
Protein Name: H2B Clustered Histone 8
Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
More Common Targets
H2BC9 | H2BP1 | H2BP2 | H2BP3 | H2BW1 | H2BW2 | H2BW4P | H3-3A | H3-3B | H3-4 | H3-5 | H3-7 | H3C1 | H3C10 | H3C11 | H3C12 | H3C13 | H3C14 | H3C15 | H3C2 | H3C3 | H3C4 | H3C6 | H3C7 | H3C8 | H3P16 | H3P36 | H3P37 | H3P44 | H3P5 | H3P6 | H4C1 | H4C11 | H4C12 | H4C13 | H4C14 | H4C15 | H4C16 | H4C2 | H4C3 | H4C4 | H4C5 | H4C6 | H4C7 | H4C8 | H4C9 | H6PD | HAAO | HABP2 | HABP4 | HACD1 | HACD2 | HACD3 | HACD4 | HACE1 | HACL1 | HADH | HADHA | HADHAP1 | HADHB | HAFML | HAGH | HAGHL | HAGLR | HAGLROS | HAL | HAMP | HAND1 | HAND2 | HAND2-AS1 | HAO1 | HAO2 | HAO2-IT1 | HAP1 | HAPLN1 | HAPLN2 | HAPLN3 | HAPLN4 | HAPSTR1 | HAR1A | HAR1B | HARBI1 | HARS1 | HARS2 | HAS1 | HAS2 | HAS2-AS1 | HAS3 | HASPIN | HAT1 | HAUS1 | HAUS1P1 | HAUS2 | HAUS3 | HAUS4 | HAUS5 | HAUS6 | HAUS7 | HAUS8 | HAVCR1
