Study on GYS2: Enzyme Function and Potential Drug Target (G2998)

Study on GYS2: Enzyme Function and Potential Drug Target

GLYCOGEN Synthase 2 (GYS2) is a protein that plays a crucial role in the metabolism of glycogen, which is a complex carbohydrate that is stored in the liver for energy reserve. GYS2 is a key enzyme in the glycogen biosynthesis pathway, and its dysfunction has been linked to a number of diseases, including obesity, type 2 diabetes, and liver disease. As a result, GYS2 has emerged as a promising drug target and a potential biomarker for a range of diseases.

GYS2 is a member of the glycogen synthase family, which includes a number of different enzymes involved in the biosynthesis of glycogen. The most well-studied member of this family is GYS1, which is also a key enzyme in the glycogen biosynthesis pathway. GYS1 and GYS2 are closely related genetically, and they share a high degree of sequence identity, suggesting that they may have similar functions.

GYS2 is widely expressed in various tissues and cells, including the liver, muscle, and heart. It is highly enriched in the liver, where it is the main enzyme responsible for the initial step in the biosynthesis of glycogen. In the liver, GYS2 is located in the hepatocellular cytoplasm and is associated with the endoplasmic reticulum. GYS2 is also expressed in other tissues, including muscle and heart, where it plays a role in the biosynthesis of glycogen in the muscle fibers.

GYS2 is involved in the synthesis of two different forms of glycogen, including the slow-twitch (stored) form and the fast-twitch (used) form. The slow-twitch form of glycogen is primarily stored in the liver, while the fast-twitch form is primarily used by the muscle to generate energy during intense exercise. The biosynthesis of glycogen is a complex process that involves a number of different enzymes, including GYS2, GYS1, and

Protein Name: Glycogen Synthase 2

Functions: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan

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GZF1 | GZMA | GZMB | GZMH | GZMK | GZMM | H1-0 | H1-1 | H1-10 | H1-10-AS1 | H1-2 | H1-3 | H1-4 | H1-5 | H1-6 | H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1 | H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P | H2BC21 | H2BC26 | H2BC27P | H2BC3 | H2BC4 | H2BC5 | H2BC6 | H2BC7 | H2BC8 | H2BC9 | H2BP1 | H2BP2 | H2BP3 | H2BW1 | H2BW2 | H2BW4P | H3-3A | H3-3B | H3-4 | H3-5 | H3-7 | H3C1 | H3C10 | H3C11 | H3C12 | H3C13 | H3C14 | H3C15 | H3C2 | H3C3 | H3C4 | H3C6 | H3C7 | H3C8 | H3P16 | H3P36 | H3P37 | H3P44 | H3P5 | H3P6 | H4C1 | H4C11