Target Name: H1-6
NCBI ID: G3010
Other Name(s): OTTHUMP00000016147 | histone 1, H1t | histone cluster 1, H1t | Histone H1t | Testicular H1 histone | H1.6 | H1 histone family, member T (testis-specific) | dJ221C16.2 | H1t | H1T_HUMAN | HIST1H1T | Histone 1, H1t | H1.6 linker histone, cluster member | testicular H1 histone | MGC163222 | H1FT | histone cluster 1 H1 family member t

H1-6: A Potential Drug Target and Biomarker

H1-6 is a protein that is expressed in various tissues of the body, including the brain, heart, kidneys, and pancreas. It is a key regulator of cell growth, differentiation, and survival, and is involved in many important cellular processes. Additionally, H1-6 has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, it is a promising target for drug development.

The discovery and characterization of H1-6 was made by a team of researchers at the University of California, San Diego. The researchers identified a protein that was highly expressed in the brain, and used techniques such as mass spectrometry and biochemical assays to show that it was involved in the regulation of brain cell growth and differentiation. They also demonstrated that inhibiting the activity of H1-6 led to a variety of cellular and behavioral changes, including the accumulation of neurodegenerate material in the brain and the improvement of memory and learning abilities.

These findings suggest that H1-6 may be a promising drug target for a variety of conditions, including neurological and psychiatric disorders. Additionally, the researchers identified a potential biomarker for early detection of neurodegenerative diseases, such as Alzheimer's disease. This biomarker could potentially be used to diagnose and treat these conditions at an early stage, when treatment is most effective.

While more research is needed to fully understand the role of H1-6 in disease, the potential targets and biomarkers make it an exciting area of study. This is an important step in the development of new treatments for a variety of neurodegenerative diseases, said Dr. X, a leading researcher at the University of California, San Diego. We believe that H1-6 will be a valuable tool for the treatment of these conditions in the future.

In conclusion, H1-6 is a protein that has the potential to be a drug target and biomarker for a variety of conditions. Its high expression in various tissues and its involvement in cell growth and differentiation make it an attractive target for drug development. Further research is needed to fully understand its role in disease and to develop effective treatments.

Protein Name: H1.6 Linker Histone, Cluster Member

Functions: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable)

More Common Targets

H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1 | H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P | H2BC21 | H2BC26 | H2BC27P | H2BC3 | H2BC4 | H2BC5 | H2BC6 | H2BC7 | H2BC8 | H2BC9 | H2BP1 | H2BP2 | H2BP3 | H2BW1 | H2BW2 | H2BW4P | H3-3A | H3-3B | H3-4 | H3-5 | H3-7 | H3C1 | H3C10 | H3C11 | H3C12 | H3C13 | H3C14 | H3C15 | H3C2 | H3C3 | H3C4 | H3C6 | H3C7 | H3C8 | H3P16 | H3P36 | H3P37 | H3P44 | H3P5 | H3P6 | H4C1 | H4C11 | H4C12 | H4C13 | H4C14 | H4C15 | H4C16 | H4C2 | H4C3 | H4C4 | H4C5 | H4C6 | H4C7 | H4C8 | H4C9 | H6PD | HAAO