H2AC6: A Potential Drug Target for DNA Replication and Gene Expression

H2AC6: A Potential Drug Target for DNA Replication and Gene Expression

Histone cluster 1 (H2A) is a family of proteins that play a critical role in the regulation of gene expression and DNA replication. H2AC6, also known as H2A cluster 6, is a member of the H2A family that is expressed in various tissues and cells. The H2A family has been identified as a potential drug target due to its involvement in various cellular processes, including DNA replication, gene expression, and cell cycle regulation.

The H2A family consists of several subfamilies, including H2A1, H2A2, H2A3, H2A4, H2A5, and H2A6. H2AC6 is a member of the H2A6 subfamily, which is characterized by the presence of the amino acid Lys20 and the presence of a unique N-terminal domain.

H2AC6 is a 21-kDa protein that is expressed in various tissues, including muscle, heart, brain, and liver. It is highly homogeneous and has a single known function, which is to participate in the regulation of DNA replication. H2AC6 is involved in the formation of the euchromatin-proximal chromatin domain, which is the region of DNA that is accessible to the machinery of DNA replication.

H2AC6 plays a critical role in the regulation of DNA replication by interacting with the protein DNAA1. DNAA1 is a component of the replication complex I (RCI), which is responsible for the recruitment of the necessary enzymes for DNA replication. H2AC6 interacts with DNAA1 and helps to regulate the activity of the RCI.

In addition to its role in DNA replication, H2AC6 is also involved in the regulation of gene expression. It has been shown to play a role in the regulation of various gene expression pathways, including cell cycle progression, apoptosis, and inflammation. H2AC6 has been shown to interact with the protein p21, which is a negative regulator of the p53 tumor suppressor gene. p21 is a potential drug target for cancer treatment.

H2AC6 is also involved in the regulation of cell cycle progression. It has been shown to play a role in the G1 phase of the cell cycle and has been shown to interact with the protein p20, which is a positive regulator of the p21 gene. p20 is a potential drug target for diseases associated with cell cycle dysfunction, such as cancer.

In conclusion, H2AC6 is a protein that is involved in various cellular processes, including DNA replication and gene expression. It is a potential drug target due to its involvement in these processes and has been shown to interact with several proteins that are involved in the regulation of cellular processes. Further research is needed to fully understand the role of H2AC6 in the regulation of DNA replication and gene expression.

Protein Name: H2A Clustered Histone 6

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

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H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1 | H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P | H2BC21 | H2BC26 | H2BC27P | H2BC3 | H2BC4 | H2BC5 | H2BC6 | H2BC7 | H2BC8 | H2BC9 | H2BP1 | H2BP2 | H2BP3 | H2BW1 | H2BW2 | H2BW4P | H3-3A | H3-3B | H3-4 | H3-5 | H3-7 | H3C1 | H3C10 | H3C11 | H3C12 | H3C13 | H3C14 | H3C15 | H3C2 | H3C3 | H3C4 | H3C6 | H3C7 | H3C8 | H3P16 | H3P36 | H3P37 | H3P44 | H3P5 | H3P6 | H4C1 | H4C11 | H4C12 | H4C13 | H4C14 | H4C15 | H4C16 | H4C2 | H4C3 | H4C4 | H4C5 | H4C6 | H4C7 | H4C8 | H4C9 | H6PD | HAAO | HABP2 | HABP4 | HACD1 | HACD2 | HACD3 | HACD4 | HACE1 | HACL1 | HADH | HADHA | HADHAP1 | HADHB | HAFML | HAGH | HAGHL | HAGLR | HAGLROS | HAL | HAMP | HAND1 | HAND2 | HAND2-AS1 | HAO1