Target Name: GTPBP3
NCBI ID: G84705
Other Name(s): mitochondrial GTP-binding protein 1 | TRNA modification GTPase GTPBP3, mitochondrial (isoform V) | GTP binding protein 3, mitochondrial | GTP binding protein 3 (mitochondrial) | Mitochondrial GTP-binding protein 1 | Mitochondrial GTP binding protein | tRNA modification GTPase GTPBP3, mitochondrial | GTPB3_HUMAN | GTPBP3 variant IV | GTPBP3 variant VII | MTGP1 | GTPBP3 variant V | TRNA modification GTPase GTPBP3, mitochondrial (isoform VII) | GTP-binding protein 3 | GTPBG3 | TRNA modification GTPase GTPBP3, mitochondrial (isoform IV) | GTP binding protein 3, mitochondrial, transcript variant IV | GTP binding protein 3, mitochondrial, transcript variant VII | GTP binding protein 3, mitochondrial, transcript variant V | MSS1 | COXPD23 | FLJ14700 | THDF1

GTPBP3: A Potential Drug Target and Biomarker for Mitochondrial Disorders

Guanosine triphosphate (GTP) is a crucial molecule in cell signaling that plays a vital role in various cellular processes. The mitochondrial GTP-binding protein 1 (GTPBP3) is a protein that binds to GTP and facilitates the transfer of this molecule to the mitochondrial fission complex during the process of mitochondrial fission. In recent years, the discovery of GTPBP3 as a potential drug target and biomarker for mitochondrial disorders has gained significant attention in the scientific community.

GTPBP3 is a 21-kDa protein that is expressed in most tissues of the body, including the brain, heart, and muscle. It is composed of a N-terminal transmembrane domain, a catalytic C-terminus, and a C-terminal protein domain that contains a GTP-binding site. The GTP-binding site is the most well-known part of GTPBP3, as it is the site where the protein binds to GTP.

GTPBP3 functions as a critical regulator of mitochondrial fission, which is the process by which the mitochondria divide and generate new energy. During mitochondrial fission, GTPBP3 helps to ensure that the fission event proceeds smoothly and that the resulting mitochondrial daughter cells are properly separated from the mother cell.

GTPBP3 has also been shown to play a role in the regulation of various cellular processes that are not directly related to mitochondrial fission. For example, GTPBP3 has been shown to regulate the formation of new blood vessels in the brain, which is thought to be an important step in the development and progression of certain neurological disorders. Additionally, GTPBP3 has been shown to play a role in the regulation of cell growth and differentiation, as well as in the regulation of cellular signaling pathways that are involved in cell survival and proliferation.

As a potential drug target, GTPBP3 has the potential to be used to treat a wide range of mitochondrial disorders, including those that are caused by genetic mutations, such as the progressive motor neuron disease (PMSD) and the mitochondrial encephalomyopathy (MEN) that are inherited from an autosomal dominant manner. In addition, GTPBP3 may also be a useful biomarker for the diagnosis of certain mitochondrial disorders, as changes in GTPBP3 expression levels have been observed in a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In conclusion, GTPBP3 is a protein that plays a critical role in the regulation of various cellular processes that are involved in cell signaling and survival. Its function as a potential drug target and biomarker for mitochondrial disorders makes it an attractive target for researchers to investigate and develop new treatments for a wide range of neurodegenerative diseases.

Protein Name: GTP Binding Protein 3, Mitochondrial

Functions: GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs

More Common Targets

GTPBP4 | GTPBP6 | GTPBP8 | GTSCR1 | GTSE1 | GTSE1-DT | GTSF1 | GTSF1L | Guanine nucleotide-binding protein G(t) complex | Guanylate cyclase | Guanylate kinase (isoform b) | GUCA1A | GUCA1B | GUCA1C | GUCA2A | GUCA2B | GUCD1 | GUCY1A1 | GUCY1A2 | GUCY1B1 | GUCY1B2 | GUCY2C | GUCY2D | GUCY2EP | GUCY2F | GUCY2GP | GUF1 | GUK1 | GULOP | GULP1 | GUSB | GUSBP1 | GUSBP11 | GUSBP12 | GUSBP14 | GUSBP15 | GUSBP17 | GUSBP2 | GUSBP3 | GUSBP4 | GUSBP5 | GUSBP8 | GVINP1 | GVQW3 | GXYLT1 | GXYLT1P3 | GXYLT1P4 | GXYLT1P6 | GXYLT2 | GYG1 | GYG2 | GYPA | GYPB | GYPC | GYPE | GYS1 | GYS2 | GZF1 | GZMA | GZMB | GZMH | GZMK | GZMM | H1-0 | H1-1 | H1-10 | H1-10-AS1 | H1-2 | H1-3 | H1-4 | H1-5 | H1-6 | H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1