Target Name: GTPBP8
NCBI ID: G29083
Other Name(s): GTPBP8 variant 1 | GTP binding protein 8 (putative) | GTP-binding protein 8 | GTP-binding protein 8 (isoform 1) | GTPB8_HUMAN | GTP binding protein 8 (putative), transcript variant 1 | HSPC135

GTPBP8: A Potential Drug Target for Various Diseases

GTPBP8 (GTPBP8 variant 1) is a protein that is expressed in almost all eukaryotic cells and plays an important role in biological processes such as cell signaling, metabolism, and apoptosis. GTPBP8 is a GTPase 尾 subunit that catalyzes the binding and detachment of GTP through GTPase activity in cells, thereby regulating intracellular signaling and metabolism.

In recent years, GTPBP8 has been considered as a potential drug target for various diseases. The expression pattern of GTPBP8 in various cancers is related to tumor progression and invasion ability, so it is considered an important tumor therapeutic target. At the same time, the expression pattern of GTPBP8 in neurodegenerative diseases is related to neuronal damage and apoptosis, so it is considered a potential therapeutic target for neurological diseases.

The pharmacological properties and mechanism of action of GTPBP8 are very unique. GTPBP8 is a protein that can be treated orally or injected. Because GTPBP8 is an intracellular protein, it can function within cells without being affected by blood circulation. Furthermore, the activity of GTPBP8 can be bound and modulated by specific antibodies, allowing precise control of its expression level.

At present, clinical research on GTPBP8 mainly focuses on the nervous system and tumor fields. In the nervous system, GTPBP8 has been used to treat diseases such as Parkinson's disease, Alzheimer's disease and depression. In terms of tumors, GTPBP8 has been used to treat diseases such as breast cancer, lung cancer, and prostate cancer.

The mechanism of action of GTPBP8 is complex. GTPBP8 catalyzes the binding and detachment of GTP through GTPase activity, thereby regulating intracellular signaling and metabolism. The GTPase activity of GTPBP8 can be bound and regulated by specific antibodies, allowing precise control of its expression level. In addition, the expression pattern of GTPBP8 can be regulated by a variety of signaling molecules, such as insulin, thyroid hormones, and growth factors.

GTPBP8 expression patterns in neurodegenerative diseases correlate with neuronal damage and apoptosis. Studies have shown that the expression level of GTPBP8 is positively correlated with the degree of neuronal damage and the number of neuronal apoptosis. In addition, the expression level of GTPBP8 can also be regulated by molecular mechanisms related to neurodegenerative diseases, such as the regulation of neuronal apoptosis, neuronal growth and changes in neuronal synapses.

In the field of cancer, the expression pattern of GTPBP8 is related to tumor progression and invasion ability. Studies have shown that the expression level of GTPBP8 is related to tumor invasion

Protein Name: GTP Binding Protein 8 (putative)

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GTSCR1 | GTSE1 | GTSE1-DT | GTSF1 | GTSF1L | Guanine nucleotide-binding protein G(t) complex | Guanylate cyclase | Guanylate kinase (isoform b) | GUCA1A | GUCA1B | GUCA1C | GUCA2A | GUCA2B | GUCD1 | GUCY1A1 | GUCY1A2 | GUCY1B1 | GUCY1B2 | GUCY2C | GUCY2D | GUCY2EP | GUCY2F | GUCY2GP | GUF1 | GUK1 | GULOP | GULP1 | GUSB | GUSBP1 | GUSBP11 | GUSBP12 | GUSBP14 | GUSBP15 | GUSBP17 | GUSBP2 | GUSBP3 | GUSBP4 | GUSBP5 | GUSBP8 | GVINP1 | GVQW3 | GXYLT1 | GXYLT1P3 | GXYLT1P4 | GXYLT1P6 | GXYLT2 | GYG1 | GYG2 | GYPA | GYPB | GYPC | GYPE | GYS1 | GYS2 | GZF1 | GZMA | GZMB | GZMH | GZMK | GZMM | H1-0 | H1-1 | H1-10 | H1-10-AS1 | H1-2 | H1-3 | H1-4 | H1-5 | H1-6 | H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT