Target Name: GTSE1
NCBI ID: G51512
Other Name(s): GTSE-1 | G2 and S-phase expressed 1 | Protein B99 homolog | protein B99 homolog | B99 | G2 and S phase-expressed protein 1 | GTSE1_HUMAN | B99 homolog | Lnc_bc060912 | G-2 and S-phase expressed 1 | OTTHUMP00000028851

Discovering The Potential Role of GTSE-1 in Drug Targets

Guanosine Triphosphate-1 (GTSE-1) is a protein that exists in a variety of cells and tissues. Its function is to catalyze phosphorylation reactions. GTSE-1 plays an important role in biological processes such as cell signaling, metabolic regulation, cell proliferation and apoptosis. In recent years, researchers have conducted in-depth studies on the biological functions of GTSE-1 and also discovered the potential role of GTSE-1 in drug targets. This article will discuss the biological functions and drug targets of GTSE-1.

Biological functions of GTSE-1
GTSE-1 is a transduction enzyme that participates in multiple signaling pathways within cells. In the GTP (guanosine triphosphate) signaling pathway, GTSE-1 catalyzes the binding of GTP to intracellular receptor proteins, thereby triggering a series of signaling reactions. In addition, GTSE-1 is also involved in biological processes such as cell proliferation and apoptosis, regulating cell cycle, cell growth and cell death.

During tumor occurrence and development, the expression level of GTSE-1 changes. Studies have found that the expression level of GTSE-1 is positively correlated with various tumor types (such as lung cancer, liver cancer, breast cancer, etc.). In addition, the expression level of GTSE-1 is also closely related to the invasion and metastasis ability of tumors. Therefore, by regulating the biological functions of GTSE-1, we can effectively intervene in tumor occurrence and development.

Drug Targets of GTSE-1 Because GTSE-1 has important functions in biological processes, it is widely used in drug development. At present, drug research on GTSE-1 mainly focuses on the following aspects:

1. GTSE-1 inhibitors

Inhibitors are a class of molecules that inhibit the biological activity of GTSE-1. By inhibiting the function of GTSE-1, the rate of intracellular signal transduction can be reduced, thereby achieving the purpose of treating tumors. At present, inhibitors targeting GTSE-1 mainly include organic small molecule compounds, macromolecule inhibitors and drug coupling agents.

2. GTSE-1 agonists

Agonists are a class of molecules that enhance the biological activity of GTSE-1. By stimulating the function of GTSE-1, the rate of intracellular signaling can be promoted, thereby activating a series of biological processes. At present, agonists targeting GTSE-1 mainly include organic small molecule compounds, macromolecular agonists and drug coupling agents.

3. GTSE-1 antagonist

Antagonists are a class of molecules that block the binding of GTSE-1 to GTP. By blocking the binding of GTSE-1 to GTP, the rate of intracellular signaling can be reduced, thereby inhibiting the growth and spread of tumor cells. At present, antagonists against GTSE-1 mainly include organic small molecule compounds and drug coupling agents.

4. Gene therapy of GTSE-1

Gene therapy is a method of treating tumors by introducing exogenous genes into target cells through genetic engineering technology. Gene therapy for GTSE-1 mainly includes the following aspects:

(1) Gene editing technology: Through gene editing technology, gene fragments with therapeutic effects are introduced into target cells to achieve the inhibitory effect on GTSE-1.

(2) Gene targeting technology: Through gene targeting technology, gene fragments with therapeutic effects are combined with tumor cell-specific receptors to achieve antagonism against GTSE-1.

(3) Gene combination therapy: By combining gene fragments with therapeutic effects with molecules such as tumor cell-specific receptors and drug coupling agents, the inhibitory effect on GTSE-1 can be achieved.

in conclusion
GTSE-1 has important functions in biological processes and is an important target for drug development. At present, drug research on GTSE-1 mainly includes inhibitors, agonists, antagonists and gene therapy. However, drug research targeting GTSE-1 is still in its preliminary stages, and further in-depth research on the biological functions and drug targets of GTSE-1 is needed to provide more effective drugs for clinical treatment.

Protein Name: G2 And S-phase Expressed 1

Functions: May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression

More Common Targets

GTSE1-DT | GTSF1 | GTSF1L | Guanine nucleotide-binding protein G(t) complex | Guanylate cyclase | Guanylate kinase (isoform b) | GUCA1A | GUCA1B | GUCA1C | GUCA2A | GUCA2B | GUCD1 | GUCY1A1 | GUCY1A2 | GUCY1B1 | GUCY1B2 | GUCY2C | GUCY2D | GUCY2EP | GUCY2F | GUCY2GP | GUF1 | GUK1 | GULOP | GULP1 | GUSB | GUSBP1 | GUSBP11 | GUSBP12 | GUSBP14 | GUSBP15 | GUSBP17 | GUSBP2 | GUSBP3 | GUSBP4 | GUSBP5 | GUSBP8 | GVINP1 | GVQW3 | GXYLT1 | GXYLT1P3 | GXYLT1P4 | GXYLT1P6 | GXYLT2 | GYG1 | GYG2 | GYPA | GYPB | GYPC | GYPE | GYS1 | GYS2 | GZF1 | GZMA | GZMB | GZMH | GZMK | GZMM | H1-0 | H1-1 | H1-10 | H1-10-AS1 | H1-2 | H1-3 | H1-4 | H1-5 | H1-6 | H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1