Target Name: GUCA2B
NCBI ID: G2981
Other Name(s): Guanylate cyclase activator 2B | GCAP-II | prepro-uroguanylin | Guanylate cyclase C-activating peptide II | uroguanylin | Uroguanylin | UGN | guanylate cyclase activator 2B | GUC2B_HUMAN | Guanylate cyclase C-activating peptide 2

GUCA2B: A Potential Drug Target and Biomarker

Guanylate cyclase activator 2B (GUCA2B) is a protein that is expressed in various tissues and cells throughout the body. It plays a crucial role in the regulation of cell signaling pathways, including the cAMP signaling pathway. This pathway is involved in various physiological processes, including cell growth, differentiation, and inflammation. Therefore, changes in the levels of GUCA2B have been associated with various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

GUCA2B is a member of the cyclic AMP-response element-binding protein (CABP) family, which includes proteins that regulate the levels of intracellular cyclic AMP (cAMP). The CABP family is a large family of proteins that include four subfamilies: the nucleotide-binding subfamily (NBS), the dephosphorylated subfamily (DSP), the kinase-activated subfamily (KAS), and the GDP-binding subfamily (GBS). GUCA2B is a member of the DSP subfamily and is responsible for activating the cAMP signaling pathway.

GUCA2B is a 21-kDa protein that is expressed in various tissues, including muscle, heart, brain, and pancreas. It is primarily localized to the cytoplasm and is involved in the regulation of various cellular processes, including cell signaling, DNA replication, and protein synthesis. GUCA2B has been shown to play a role in the regulation of cell proliferation, differentiation, and survival.

GUCA2B has also been shown to be involved in the regulation of various signaling pathways, including the cAMP signaling pathway. This pathway is involved in the regulation of various cellular processes, including cell growth, differentiation, and inflammation. Therefore, changes in the levels of GUCA2B have been associated with various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

One of the most significant findings related to GUCA2B is its involvement in the regulation of the cAMP signaling pathway. This pathway is involved in the regulation of various cellular processes, including cell growth, differentiation, and inflammation. Increased levels of GUCA2B have been shown to promote the activity of the cAMP signaling pathway, leading to increased cell proliferation and differentiation.

In addition to its role in the regulation of the cAMP signaling pathway, GUCA2B has also been shown to play a role in the regulation of DNA replication. This protein has been shown to interact with the protein p21, which is a critical regulator of the DNA replication pathway. Therefore, changes in the levels of GUCA2B have been associated with various diseases, including cancer.

GUCA2B has also been shown to play a role in the regulation of protein synthesis. This protein has been shown to interact with the protein FIP1, which is a critical regulator of protein synthesis. Therefore, changes in the levels of GUCA2B have been associated with various diseases, including neurodegenerative diseases.

In conclusion, GUCA2B is a protein that is involved in the regulation of various cellular processes, including cell signaling, DNA replication, and protein synthesis. Its levels have been associated with various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Therefore, GUCA2B is a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of GUCA2B in the regulation of cellular processes and its potential as a drug target.

Protein Name: Guanylate Cyclase Activator 2B

Functions: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport

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GUCD1 | GUCY1A1 | GUCY1A2 | GUCY1B1 | GUCY1B2 | GUCY2C | GUCY2D | GUCY2EP | GUCY2F | GUCY2GP | GUF1 | GUK1 | GULOP | GULP1 | GUSB | GUSBP1 | GUSBP11 | GUSBP12 | GUSBP14 | GUSBP15 | GUSBP17 | GUSBP2 | GUSBP3 | GUSBP4 | GUSBP5 | GUSBP8 | GVINP1 | GVQW3 | GXYLT1 | GXYLT1P3 | GXYLT1P4 | GXYLT1P6 | GXYLT2 | GYG1 | GYG2 | GYPA | GYPB | GYPC | GYPE | GYS1 | GYS2 | GZF1 | GZMA | GZMB | GZMH | GZMK | GZMM | H1-0 | H1-1 | H1-10 | H1-10-AS1 | H1-2 | H1-3 | H1-4 | H1-5 | H1-6 | H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1 | H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P | H2BC21