GSTA4: Key Enzyme in Xenobiotic Detoxification (G2941)

Target Name: GSTA4

NCBI ID: G2941

GSTA4: Key Enzyme in Xenobiotic Detoxification

Glutathione S-transferase A4 (GSTA4) is a gene that encodes a protein known as GSTA4, which is a key enzyme in the detoxification process of xenobiotics, such as drugs, toxins, and environmental pollutants. GSTA4 is expressed in many different tissues and cells throughout the body, including the liver, kidney, and intestine, and is involved in the detoxification and elimination of these substances.

GSTA4 is a member of the GST family of enzymes, which are responsible for the detoxification of a wide variety of xenobiotics. The GST family consists of 28 different enzymes, including GSTA1-7, GSTB, GSTC, and GSTE6, which are found in different tissues and cells throughout the body. These enzymes share a common catalytic site and are able to detoxify a wide variety of xenobiotics by catalyzing the transfer of a gamma-glutamyl group from the xenobiotic to the enzyme's active site.

GSTA4 is a key enzyme in the detoxification process of many different xenobiotics, including drugs, toxins, and environmental pollutants. It is expressed in many different tissues and cells throughout the body, including the liver, kidney, and intestine, and is involved in the detoxification and elimination of these substances.

One of the unique features of GSTA4 is its ability to transfer a gamma-glutamyl group from the xenobiotic to the enzyme's active site. This transfer of the gamma-glutamyl group is a critical step in the detoxification process, as it allows the enzyme to remove the toxic xenobiotic from the body. GSTA4 is also involved in the regulation of the activity of other GST enzymes, which may have important roles in the detoxification of a wide variety of xenobiotics.

In addition to its role in the detoxification process, GSTA4 is also involved in the regulation of cellular processes that are important for maintaining cellular health and function. For example, GSTA4 has been shown to play a role in the regulation of cell signaling pathways, including the production of reactive oxygen species (ROS) and the detoxification of oxidative stress.

GSTA4 is also a potential drug target, as its role in the detoxification process makes it a potential target for drugs that are designed to disrupt the detoxification process. For example, GSTA4 has been shown to play a role in the detoxification of drug-induced neurotoxicity, and inhibitors of GSTA4 have been shown to be effective in protecting against this type of neurotoxicity.

In addition to its potential as a drug target, GSTA4 is also a potential biomarker for a variety of diseases. For example, GSTA4 has been shown to be involved in the development and progression of certain types of cancer, and may be a useful biomarker for monitoring the effectiveness of cancer treatments. In addition, GSTA4 has been shown to be involved in the regulation of cellular processes that are important for maintaining cellular health and function, and may be a useful biomarker for a variety of diseases, including neurodegenerative disorders and autoimmune diseases.

Overall, GSTA4 is a key enzyme that is involved in the detoxification process of many different xenobiotics. Its ability to transfer a gamma-glutamyl group from the xenobiotic to the enzyme's active site is a critical step in this process, and it is also involved in the regulation of cellular processes that are important for maintaining cellular health and function. As a result, GSTA4 is a potential drug target and biomarker for a variety of diseases.

Protein Name: Glutathione S-transferase Alpha 4

Functions: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE)

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