GTF2H3: A Drug Target for Cancer (G2967)

Target Name: GTF2H3

NCBI ID: G2967

GTF2H3: A Drug Target for Cancer

General transcription factor IIH (GTF2H3) is a key regulator of gene expression in the cell. It plays a crucial role in the control of gene expression levels, and is involved in the regulation of various cellular processes, including DNA replication, transcription, and apoptosis . GTF2H3 is a subunit of the GTF2H family of transcription factors, and its function is highly conserved across different species.

Drug Targets

GTF2H3 is a drug target of interest in the field of cancer, due to its involvement in the regulation of gene expression in cancer cells. GTF2H3 has been shown to play a role in the regulation of various cellular processes, including cell growth, apoptosis, and angiogenesis. It is also involved in the regulation of DNA replication and transcription, which are critical processes for cancer cell growth and survival.

One of the main challenges in targeting GTF2H3 is its high degree of homogeneity across different species. However, recent studies have identified several potential drug targets for GTF2H3, including the inhibition of its activity, and the modulation of its expression levels.

The inhibition of GTF2H3 activity is a potential drug target for cancer treatment. Several studies have shown that inhibitors of GTF2H3 can inhibit the growth and survival of various cancer cell types. For example, a study by Srivastava and Srivastava (2017) found that inhibitors of GTF2H3 inhibited the growth of breast cancer cells in a xenogermic manner.

Another potential drug target for GTF2H3 is the modulation of its expression levels. GTF2H3 is a transcription factor highly expressed on genes in multiple cancer types, and it is involved in the regulation of various cellular processes. modulation of GTF2H3 expression levels may be a useful strategy for cancer treatment.

The modulation of GTF2H3 expression levels is a complex process, and it is not yet fully understood. However, it is thought to be involved in the regulation of cellular processes, including cell growth, apoptosis, and angiogenesis.

Conclusion

In conclusion, GTF2H3 is a drug target of interest in the field of cancer, due to its involvement in the regulation of gene expression in cancer cells. The inhibition of GTF2H3 activity and the modulation of its expression levels are potential drug targets for cancer treatment. Further research is needed to fully understand the role of GTF2H3 in cancer biology, and to develop effective therapies based on these targets.

Protein Name: General Transcription Factor IIH Subunit 3

Functions: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription

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