GRB10: A Potential Drug Target and Biomarker (G2887)

Target Name: GRB10

NCBI ID: G2887

GRB10: A Potential Drug Target and Biomarker

GRB10 (Growth factor receptor-bound protein 10) is a protein that is expressed in various tissues and cell types throughout the body. It is a member of the GRB10 family of proteins, which are known as growth factor receptor-bound proteins (GFRs). These proteins are known for their ability to interact with and modulate the activity of cell surface receptors that are involved in various cellular processes, including cell growth, differentiation, and survival.

GRB10 is a 21-kDa protein that is expressed in a variety of tissues, including muscle, nerve, heart, and blood vessels. It is primarily localized to the cytoplasm of these cells, where it can interact with and modulate the activity of various cell surface receptors. This protein is also known as isoform c of GRB10, as it has four distinct isoforms that are produced from a single gene.

GRB10 has been shown to play a role in a variety of cellular processes, including cell growth, differentiation, and survival. For example, studies have shown that GRB10 can promote the growth and survival of various cell types, including muscle cells, nerve cells, and cancer cells. It is also known to play a role in the regulation of cellular processes that are involved in the development and progression of various diseases, including cancer.

In addition to its role in cellular processes, GRB10 is also being considered as a potential drug target or biomarker. Several studies have shown that GRB10 can be targeted by small molecules, including inhibitors of tyrosine kinase activity, which are known to have the ability to inhibit the activity of GRB10. These inhibitors have been shown to be effective in treating a variety of diseases, including cancer.

Another approach to targeting GRB10 is to use antibodies that are designed to recognize and label the protein. Studies have shown that antibodies directed against GRB10 can be used to detect and measure the level of the protein in various tissues and cell types. These antibodies have been shown to be effective in detecting and measuring the level of GRB10 in a variety of settings, including samples from cancer patients and controls.

In conclusion, GRB10 is a protein that is known for its role in various cellular processes and its potential as a drug target or biomarker. Studies have shown that GRB10 can promote the growth and survival of various cell types and that it is being considered as a potential drug target for a variety of diseases. Further research is needed to fully understand the role of GRB10 in cellular processes and its potential as a drug target.

Protein Name: Growth Factor Receptor Bound Protein 10

Functions: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2

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