EPHA8: A Protein Involved in Cell Signaling, Inflammation and Cell Adhesion

Target Name: EPHA8

NCBI ID: G2046

EPHA8: A Protein Involved in Cell Signaling, Inflammation and Cell Adhesion

EPHA8 (EPH-like kinase 3) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the Eph receptor tyrosine kinase family, which is a group of transmembrane proteins that play a crucial role in the development and maintenance of tissues and organs.

One of the key functions of EPHA8 is its role in cell signaling. It is a scaffold protein that can interact with various signaling molecules, including TGF-β1, Wnt, andNotch. These molecules are involved in cell proliferation, differentiation, and survival, and EPHA8 is thought to be involved in the regulation of these processes.

EPHA8 has also been shown to play a role in the regulation of inflammation. It is a potential target for anti-inflammatory drugs, as it has been shown to contribute to the inflammatory response in various tissues.

In addition to its role in cell signaling and inflammation, EPHA8 has also been shown to be involved in the regulation of cell adhesion. It is a protein that can interact with the cell adhesion molecule E-cadherin, and it is thought to play a role in the regulation of cell-cell adhesion.

These findings suggest that EPHA8 may be a promising drug target for a variety of diseases. Because it is involved in so many different processes in the body, it is potential that targeting EPHA8 could have a broad range of therapeutic applications.

In conclusion, EPHA8 is a protein that is expressed in various tissues throughout the body that is involved in a wide range of cellular processes. It is a potential drug target for a variety of diseases due to its role in cell signaling, inflammation, and cell adhesion. Further research is needed to fully understand the full range of its functions and potential therapeutic applications.

Protein Name: EPH Receptor A8

Functions: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity)

More Common Targets