SF3B3: A Protein with Potential as A Drug Target and Biomarker

Target Name: SF3B3

NCBI ID: G23450

SF3B3: A Protein with Potential as A Drug Target and Biomarker

SF3B3 (SF3B3_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, and skeletal muscles. It is a key regulator of the synaptic plasticity, which is the ability of the brain to change and adapt over time.

SF3B3 has been shown to play a crucial role in the regulation of neural circuits in the brain, including the formation and maintenance of long-term memory. It has also been shown to be involved in the regulation of muscle contractions and the maintenance of muscle mass.

As a drug target, SF3B3 is of interest to researchers because it has been shown to be involved in a wide range of physiological processes that are important for human health. It is also because it is relatively simple to produce, making it a potentially attractive candidate for use in drug development.

One of the key challenges in studying SF3B3 is its complex structure. SF3B3 is a protein that consists of 1,262 amino acids, and its structure is highly conserved across different species. This makes it difficult to study the protein in detail, and has limited the ability to predict its activity or interactions with other molecules.

Despite these challenges, researchers have made significant progress in the study of SF3B3. They have shown that SF3B3 is involved in a wide range of physiological processes, including the regulation of neural circuits, muscle contractions, and the regulation of inflammation. They have also identified a number of potential drug targets that are involved in these processes.

One of the most promising areas of research on SF3B3 is its role in the regulation of neural circuits. SF3B3 has been shown to play a key role in the formation and maintenance of long-term memory, and in the regulation of neurotransmitter release from synapses. This makes it a potential target for drugs that are designed to enhance memory or treat neurological disorders.

Another promising area of research on SF3B3 is its role in the regulation of muscle contractions. SF3B3 has been shown to play a key role in the regulation of muscle force production and muscle contractions. This makes it a potential target for drugs that are designed to treat muscle-related disorders, such as muscular dystrophy or myopathies.

In addition to its potential as a drug target, SF3B3 is also of interest to researchers because of its potential as a biomarker. Because SF3B3 is expressed in a wide range of tissues, it has been shown to be a potential indicator of disease, and may be used as a diagnostic or monitoring tool in a variety of diseases.

Overall, SF3B3 is a protein that is of great interest to researchers due to its complex structure and its role in a wide range of physiological processes. While further research is needed to fully understand its potential as a drug target and biomarker, the study of SF3B3 is a promising area of research that has the potential to advance human health.

Protein Name: Splicing Factor 3b Subunit 3

Functions: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077) (Probable)

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