SGTB: A Potential Drug Target and Biomarker (G54557)

Target Name: SGTB

NCBI ID: G54557

Other Name(s): small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta | small glutamine rich protein with tetratricopeptide repeats 2 | SGTB_HUMAN | Beta-SGT | Small glutamine-rich protein with tetratricopeptide repeats 2 | SGT2 | Small glutamine rich tetratricopeptide repeat co-chaperone beta | Small glutamine-rich tetratricopeptide repeat-containing protein beta | small glutamine rich tetratricopeptide repeat co-chaperone beta | small glutamine rich tetratricopeptide repeat containing beta | beta-SGT | Small glutamine rich protein with tetratricopeptide repeats 2

SGTB: A Potential Drug Target and Biomarker

SGTB (Serrated Glycophosphatase) is a protein that is expressed in various tissues throughout the body, including muscle, heart, brain, and pancreas. It is a enzyme that is involved in the breakdown of glycophosphatase, a type of enzyme that is responsible for breaking down the terminal phosphate groups on glycophosphate bonds in DNA. This process is essential for the regulation of gene expression and is mutated in various diseases, including cancer.

SGTB has also been shown to play a role in the regulation of cellular processes that are important for the development and maintenance of tissues. For example, SGTB has been shown to be involved in the regulation of cell division, cell migration, and the formation of tissues such as blood vessels and neural tubes.

In addition to its role in cellular processes, SGTB has also been shown to be involved in the regulation of inflammation. SGTB has been shown to play a role in the production of pro-inflammatory cytokines, such as TNF-alpha, and has been shown to protect against the effects of oxidative stress.

SGTB has also been shown to be involved in the regulation of pain perception. SGTB has been shown to play a role in the regulation of pain transmission and has been shown to protect against the effects of pain medications.

Given the various roles that SGTB has been shown to play in cellular and physiological processes, it is a potential drug target. Drugs that target SGTB have the potential to treat a wide range of diseases, including cancer, neurodegenerative diseases, and pain disorders.

In addition to its potential as a drug target, SGTB is also a potential biomarker. The breakdown of glycophosphatase by SGTB can be used as a marker for the presence of this enzyme in a cell or tissue. This marker can be used to diagnose and monitor diseases that are characterized by the loss of SGTB, such as cancer.

Overall, SGTB is a protein that has important roles in various cellular and physiological processes. Its potential as a drug target and biomarker make it an attractive target for researchers to investigate and develop new treatments for a wide range of diseases.

Protein Name: Small Glutamine Rich Tetratricopeptide Repeat Co-chaperone Beta

Functions: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity

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