SHank3: Key Regulator of Cell Signaling and Cellular Structure

Target Name: SHANK3

NCBI ID: G85358

SHank3: Key Regulator of Cell Signaling and Cellular Structure

SHank3 (KIAA1650) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and muscle. It is a member of the Kallikrein-related protein family and is involved in the regulation of various cellular processes that are critical for cell survival and growth.

One of the most significant functions of SHank3 is its role in the regulation of cell signaling pathways. SHank3 has been shown to play a critical role in the regulation of the protein kinase PDK4, which is a key regulator of many cellular processes that are involved in cell growth, differentiation, and survival.

In addition to its role in cell signaling pathways, SHank3 is also involved in the regulation of cellular structure and dynamics. SHank3 has been shown to play a critical role in the regulation of the cytoskeleton, which is the structure that gives cells their shape and provides support for their various cellular processes.

Another function of SHank3 is its role in the regulation of cellular responses to stimuli. SHank3 has been shown to play a critical role in the regulation of the Axon signaling pathway, which is involved in the transmission of signals from the cell body to the tips of the axons, which are the extensions of the neurons that carry signals away from the cell body.

In conclusion, SHank3 is a protein that is involved in a wide range of cellular processes that are critical for cell survival and growth. Its functions in cell signaling pathways, cytoskeleton regulation, and cellular responses to stimuli make it an attractive drug target for researchers who are interested in the development of new treatments for a variety of diseases.

Protein Name: SH3 And Multiple Ankyrin Repeat Domains 3

Functions: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation

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