SIGLEC12: Potential Drug Target for Insulin Secretion and Other Processes

Target Name: SIGLEC12

NCBI ID: G89858

SIGLEC12: Potential Drug Target for Insulin Secretion and Other Processes

SIGLEC12, or sigleclone-12, is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the SIGLEC family, which is known for its role in intracellular signaling. SIGLEC12 has been shown to play a role in the regulation of insulin secretion from the pancreas, and is potential drug target for the treatment of various diseases.

SIGLEC12 is a 21-kDa protein that is expressed in the pancreas, spleen, liver, and other tissues. It is a member of the SIGLEC family, which includes several other proteins that are involved in intracellular signaling. The SIGLEC family is characterized by the presence of a single transmembrane domain and a C-terminus that is involved in protein-protein interactions.

SIGLEC12 has been shown to play a role in the regulation of insulin secretion from the pancreas. Insulin is a hormone that is produced by the pancreas and helps to regulate the levels of glucose in the body. SIGLEC12 has been shown to interact with the protein known as Insulin-like growth factor 1 (IGF-1), which is also known as insulin. This interaction between SIGLEC12 and IGF-1 has been shown to play a role in the regulation of insulin secretion from the pancreas.

In addition to its role in insulin secretion, SIGLEC12 has also been shown to be involved in the regulation of other physiological processes. For example, it has been shown to be involved in the regulation of cell adhesion, and has been shown to interact with the protein known as E-cadherin. This interaction between SIGLEC12 and E-cadherin has been shown to play a role in the regulation of cell adhesion and the development of cancer.

SIGLEC12 has also been shown to be involved in the regulation of the immune response. For example, it has been shown to interact with the protein known as PD-L1, which is a protein that is expressed in the immune system and has been shown to play a role in the regulation of immune responses. This interaction between SIGLEC12 and PD-L1 has been shown to play a role in the regulation of the immune response and the development of autoimmune diseases.

In conclusion, SIGLEC12 is a protein that is expressed in various tissues throughout the body and is involved in the regulation of insulin secretion, the regulation of cell adhesion, and the regulation of the immune response. Its potential as a drug target makes it an attractive target for the treatment of various diseases. Further research is needed to fully understand the role of SIGLEC12 in these processes and to develop effective treatments.

Protein Name: Sialic Acid Binding Ig Like Lectin 12

Functions: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

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