SLC10A6: A Potential Drug Target and Biomarker (G345274)

Target Name: SLC10A6

NCBI ID: G345274

Other Name(s): Solute carrier family 10 member 6 | solute carrier family 10 (sodium/bile acid cotransporter family), member 6 | Sodium-dependent organic anion transporter | SOAT | solute carrier family 10 (sodium/bile acid cotransporter), member 6 | Solute carrier family 10, 6 (sodium/bile acid cotransporter family, SLC10A6) | SOAT_HUMAN | solute carrier family 10 member 6

SLC10A6: A Potential Drug Target and Biomarker

Solute Carrier Family 10 (SLC10) member 6, also known as SLC10A6, is a protein that is expressed in various tissues and cells throughout the body. It plays a crucial role in the transport of various molecules, including neurotransmitters, across the blood-brain barrier (BBB), which is a specialized barrier that separates the brain from the surrounding blood vessels.

SLC10A6 is a member of the SLC10 family, which is known for its ability to transport a wide variety of molecules across the BBB. The SLC10A6 gene was first identified in 2002 and has since been expressed in many different tissues and cells, including brain, heart , and pancreas.

One of the key functions of SLC10A6 is its role in the transport of neurotransmitters across the BBB. Neurotransmitters are chemical messengers that are used by the brain to communicate with other cells and tissues. However, because the BBB is so tight and selective, it is difficult for many neurotransmitters to reach the brain. SLC10A6 helps to facilitate this process by transporting them across the barrier.

SLC10A6 has also been shown to be involved in the transport of other molecules across the BBB, including drugs that are used to treat various psychiatric and neurological disorders. For example, SLC10A6 has been shown to transport the drug escitalopram (an antidepressant) across the BBB . This suggests that SLC10A6 may be a potential drug target for treating psychiatric disorders.

In addition to its role in drug transport, SLC10A6 has also been shown to be involved in the regulation of various cellular processes. For example, SLC10A6 has been shown to regulate the amount of a protein called Transient receptor potential cation channel subfamily 4 (TRPV4) ion channels in the brain. TRPV4 channels are involved in the sensation of pain and are thought to be involved in the development of certain psychiatric disorders. SLC10A6 may be involved in the regulation of TRPV4 channels in the brain, which could have implications for the development and treatment of psychiatric disorders.

SLC10A6 has also been shown to be involved in the regulation of various signaling pathways that are involved in cancer progression. For example, SLC10A6 has been shown to be involved in the regulation of the T-cell receptor signaling pathway, which is important for the development and progression of cancer. This suggests that SLC10A6 may be a potential biomarker for the development and progression of cancer.

In conclusion, SLC10A6 is a protein that is involved in the transport of various molecules across the BBB, including neurotransmitters and other signaling molecules. Its role in drug transport and regulation of cellular processes suggests that it may be a potential drug target or biomarker for the development and treatment of psychiatric and neurological disorders. Further research is needed to fully understand the role of SLC10A6 in these processes and to determine its potential as a drug target or biomarker.

Protein Name: Solute Carrier Family 10 Member 6

Functions: Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:17491011, PubMed:23667501, PubMed:24717977, PubMed:28951227). Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (PubMed:23667501, PubMed:24717977). May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (By similarity). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium (PubMed:24717977). Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (PubMed:17491011)

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