SKIC3: A Potential Drug Target and Biomarker forSKI Complex Component SKI3

Target Name: SKIC3

NCBI ID: G9652

SKIC3: A Potential Drug Target and Biomarker forSKI Complex Component SKI3

SKIC3, or SKI complex component SKI3, is a protein that plays a crucial role in the structure and function of skeletal muscles. It is a key component of the myosin filament, which is the protein that powers muscle contraction. SKIC3 is highly conserved across different species, and its sequence is highly conserved between muscle species, providing a consistent framework for its function.

SKIC3 has been identified as a potential drug target due to its involvement in muscle function and the evidence that modifying its expression levels can impact muscle properties, such as force production and endurance. Studies have shown that SKIC3 can be regulated by various signaling pathways, including calcium signaling, protein kinase C (PKC), and mitochondrial dynamics.

Additionally, SKIC3 has been shown to play a key role in muscle disease, such as myopathies, where muscle strength and function are affected. In these diseases, SKIC3 is often expressed at higher levels than in healthy muscles, and alterations in its expression levels have been observed to impact muscle strength and function.

The identification of SKIC3 as a potential drug target has led to a growing interest in the development ofSKIC3 inhibitors for therapeutic purposes.SKIC3 inhibitors have been shown to increase muscle force production and improve muscle endurance in animal models of muscle disease.

SKIC3 is also a potential biomarker for muscle disease, as its expression levels can be affected by muscle disease and may provide a sensitive readout of muscle function. This makes SKIC3 an attractive target for diagnostic tools and potential therapeutic approaches.

SKIC3 is a member of the SKI complex, which is a protein complex involved in muscle function that is conserved across different species. The SKI complex is composed of various proteins, including SKIC1, SKIC2, and SKIC3, which work together to regulate muscle protein synthesis, degradation, and assembly.

The SKI complex is involved in many cellular processes that are essential for muscle function, including muscle protein synthesis, myogenesis, and muscle plasticity. The complex is also involved in regulating muscle force production and endurance, as well as in the regulation of muscle gene expression.

SKIC3 is a key component of the SKI complex, and its regulation of muscle function is critical for muscle health and disease. Alterations in SKIC3 expression levels have been observed in a variety of muscle diseases, including myopathies, where muscle strength and function are affected.

In myopathies, SKIC3 is often expressed at higher levels than in healthy muscles, and these alterations have been associated with muscle disease. For example, SKIC3 has been shown to be highly expressed in muscle disease caused by the myostatin gene, which encodes a protein that can inhibit muscle protein synthesis and is often mutated in myopathies.

In addition to its role in muscle disease, SKIC3 is also a potential biomarker for muscle health. Its expression levels can be affected by various factors, including muscle disease, muscle training, and muscle nutrition. This makes SKIC3 an attractive target for diagnostic tools and potential therapeutic approaches.

In conclusion, SKIC3 is a protein that plays a crucial role in the structure and function of skeletal muscles, and its regulation of muscle function is critical for muscle health and disease. The identification of SKIC3 as a potential drug target and biomarker has led to a growing interest in its study, and further research is needed to fully understand its role in muscle disease and its potential as a therapeutic approach.

Protein Name: SKI3 Subunit Of Superkiller Complex

Functions: Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C)

More Common Targets