SIX4: A Protein Involved in Many Tissues' Functionality (G51804)

Target Name: SIX4

NCBI ID: G51804

SIX4: A Protein Involved in Many Tissues' Functionality

SIX4, also known as Homeobox protein SIX4, is a protein that is expressed in a variety of tissues throughout the body. It is a member of the homeobox gene family, which is a family of genes that are involved in the development and maintenance of tissues and organs. SIX4 is a 21-kDa protein that is expressed in the liver, lung, and pancreas, among other tissues.

SIX4 is involved in a number of different functions in the body, including cell signaling, DNA replication, and wound healing. It is also involved in the development and maintenance of tissues and organs, including the liver and the pancreas. SIX4 is a critical protein for the proper functioning of many different tissues in the body, and it is a potential drug target or biomarker.

One of the key functions of SIX4 is its role in cell signaling. SIX4 is involved in the FGF signaling pathway, which is a signaling pathway that is involved in the development and maintenance of tissues and organs. This pathway is important for the development and maintenance of many different tissues, including blood vessels, skin, and hair. SIX4 is involved in the regulation of the FGF signaling pathway, and it is thought to play a key role in the development and maintenance of these tissues.

Another function of SIX4 is its role in DNA replication. SIX4 is involved in the DNA replication process, which is the process by which a cell makes a copy of its DNA before it divides. This is an important function for the development and maintenance of tissues and organs, as well as for the proper functioning of the cell. SIX4 is thought to be involved in the regulation of DNA replication, and it is a potential drug target or biomarker in this regard.

In addition to its role in cell signaling and DNA replication, SIX4 is also involved in the development and maintenance of tissues and organs. SIX4 is a critical protein for the formation of the liver, and it is involved in the regulation of the growth and development of this tissue. SIX4 is also involved in the development and maintenance of the pancreas, a gland that is responsible for producing insulin, a hormone that is used to regulate blood sugar levels.

SIX4 is also involved in the regulation of wound healing. When a tissue is injured or damaged, it is important for it to be repaired and restored to its normal state as quickly as possible. SIX4 is involved in the regulation of the wound healing process, and it is thought to play a key role in this process.

Overall, SIX4 is a protein that is involved in a number of important functions in the body. It is a potential drug target or biomarker, and it is an important protein for the proper functioning of many different tissues and organs. Further research is needed to fully understand the role of SIX4 in the body, and to determine its potential as a drug target or biomarker.

Protein Name: SIX Homeobox 4

Functions: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis

More Common Targets