SINHCAF: A Promising Drug Target (Protein FAM60A) (G58516)

Target Name: SINHCAF

NCBI ID: G58516

SINHCAF: A Promising Drug Target (Protein FAM60A)

FAM60A, also known as protein FAM60A, is a key regulator of the unfolded state of proteins. It plays a crucial role in the regulation of various cellular processes, including cell signaling, intracellular transport, and DNA replication. The protein has been identified as a potential drug target and biomarker due to its unique structure, stability, and involvement in various diseases. In this article, we will explore the SINHCAF protein, its functions, potential drug targeting, and implications for human health.

Structure and Localization

The SINHCAF protein is a 60-kDa protein that belongs to the FAM60A family. This family is characterized by the presence of a characteristic Rossmann-fold, which is a conserved structural motif that plays a crucial role in protein-protein interactions. FAM60A proteins are involved in various cellular processes, including cell signaling, intracellular transport, and DNA replication.

SINHCAF is a 60-kDa protein that consists of 115 amino acid residues. It has a characteristic Rossmann-fold at its C-terminus, which is responsible for its stability and interaction with other proteins. The protein has been shown to have a variety of functions, including:

1. Regulating protein folds: SINHCAF plays a critical role in regulating the unfolded state of various proteins. It interacts with other proteins and helps to maintain their stability in the unfolded state, which is essential for their proper function.
2. Participating in protein-protein interactions: SINHCAF is involved in various protein-protein interactions, including the interaction with the protein known as HDAC1. This interaction is crucial for the regulation of cellular processes, including cell signaling and DNA replication.
3. Controlling intracellular transport: SINHCAF is involved in the regulation of intracellular transport, including the transport of proteins to the endoplasmic reticulum (ER) and the transport of DNA to the nuclear envelope (NE).

Potential Drug Targeting

SINHCAF has been identified as a potential drug target due to its unique structure and involvement in various diseases. The SINHCAF protein is involved in various cellular processes that are crucial for human health, making it an attractive target for drug development.

1. Cancer: SINHCAF has been shown to be involved in the regulation of cell signaling, which is a crucial factor in the development and progression of cancer. Therefore, inhibiting SINHCAF function could be a promising strategy for cancer treatment.
2. Neurological Disorders: SINHCAF is involved in the regulation of intracellular transport, including the transport of neurotransmitters to the synapses. Therefore, disruptions in SINHCAF function could be a potential cause of neurological disorders.
3. Inflammatory Diseases: SINHCAF is involved in the regulation of inflammation, including the regulation of the production of pro-inflammatory cytokines. Therefore, inhibiting SINHCAF function could be a promising strategy for the treatment of inflammatory diseases.

Biomarker Potential

SINHCAF has also been identified as a potential biomarker for various diseases. Its unique structure and involvement in various cellular processes make it an attractive candidate for diagnostic applications.

1. Cancer: SINHCAF has been shown to be involved in the regulation of cell signaling, which is a crucial factor in the development and progression of cancer. Therefore, measuring SINHCAF levels in cancer samples could be a promising biomarker for cancer diagnosis.
2. Neurological Disorders: SINHCAF is involved in the regulation of intracellular transport, including the transport of neurotransmitters to the synapses. Therefore, measuring SINHCAF levels in neurological disorders could be a promising biomarker

Protein Name: SIN3-HDAC Complex Associated Factor

Functions: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity)

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