SHLD2: A Potential Drug Target and Biomarker (G54537)

Target Name: SHLD2

NCBI ID: G54537

SHLD2: A Potential Drug Target and Biomarker

SHLD2, or short for short for Sodium-Glucose Transporter 2, is a protein that is expressed in most tissues of the body. It plays a crucial role in the transport of both sodium and glucose across cell membranes. This protein is also known as GLUT2, and it is expressed in various tissues, including the brain, heart, liver, and kidneys.

SHLD2 is a transmembrane protein, which means that it spans the cell membrane and is associated with the synthesis and localization of other proteins in the cell. It is made up of four structural domains: an N-terminus, a transmembrane domain, a C-terminus, and an optional second transmembrane domain. The N-terminus of SHLD2 is located at the cytoplasm side of the cell, while the C-terminus is located at the cell surface.

SHLD2 is a member of the GLUT family, which includes other transmembrane proteins, including GLUT1 and GLUT3. These proteins are involved in the transport of various nutrients and substances across cell membranes. SHLD2 is specifically involved in the transport of sodium and glucose across cell membranes.

SHLD2 is a potential drug target because of its involvement in the regulation of ion and sugar transport. It is known to be involved in the regulation of sodium and glucose transport in various tissues, including the brain. This suggests that SHLD2 may be a useful target for the development of new treatments for conditions such as Alzheimer's disease, Parkinson's disease, and diabetes.

In addition to its potential as a drug target, SHLD2 is also a potential biomarker for certain diseases. For example, SHLD2 has been shown to be elevated in the brains of individuals with Alzheimer's disease. This suggests that SHLD2 may be a useful biomarker for the diagnosis and treatment of Alzheimer's disease.

SHLD2 is also involved in the regulation of cellular signaling pathways. It has been shown to be involved in the regulation of several signaling pathways, including the TGF-β pathway and the Wnt pathway. This suggests that SHLD2 may be a useful target for the development of new therapies for diseases that are caused by disruptions in these signaling pathways.

In conclusion, SHLD2 is a protein that is involved in the regulation of various cellular processes in the body. It is a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of SHLD2 in the regulation of ion and sugar transport, cellular signaling pathways, and other cellular processes.

Protein Name: Shieldin Complex Subunit 2

Functions: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893)

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