SIDT2: A Potential Drug Target for Cell Death and Disease (G51092)

Target Name: SIDT2

NCBI ID: G51092

Other Name(s): SIDT2_HUMAN | FLJ90656 | CGI-40 | SID1 transmembrane family member 2 | DKFZp686L17253

SIDT2: A Potential Drug Target for Cell Death and Disease

SIDT2 (SIDT2_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and muscle. It is a member of the superfamily of RNA-protein hybrids, known as nuclear export proteins (NEXPs) , and is involved in the regulation of various cellular processes.

SIDT2 has been identified as a potential drug target due to its involvement in the regulation of cell death, a crucial process that is abnormally occurring and may lead to many diseases, including neurodegenerative diseases. Additionally, SIDT2 has been shown to play a role in the development and progression of certain diseases, such as cancer.

SIDT2 is a 21-kDa protein that is expressed in the brain, heart, liver, and muscle. It is composed of a N-terminal transmembrane domain, a catalytic domain, and a C-terminal T-loop region. The transmembrane domain is responsible for the protein's ability to interact with various cellular signaling pathways, while the catalytic domain is responsible for the protein's catalytic activity. The T-loop region is involved in the regulation of SIDT2's stability and function.

SIDT2 is involved in the regulation of several cellular processes, including cell death, cell proliferation, and inflammation. One of its most well-known functions is its role in the regulation of cell death, which is a crucial process that is abnormal may lead to Many diseases, including neurodegenerative diseases.

SIDT2 has been shown to play a role in the development and progression of certain diseases, such as cancer. For example, studies have shown that high levels of SIDT2 are associated with poor prognosis in patients with pancreatic cancer, a highly aggressive form of cancer. Additionally, SIDT2 has been shown to be involved in the regulation of the blood-brain barrier, which is responsible for controlling the movement of molecules into and out of the brain. This suggests that SIDT2 may play a role in the development and progression of certain brain cancers.

SIDT2 has also been shown to be involved in the regulation of inflammation, which is a crucial process that is abnormally occurring and may lead to many diseases, including autoimmune diseases. For example, studies have shown that SIDT2 is involved in the regulation of the production of pro -inflammatory cytokines, which are involved in the development and progression of autoimmune diseases.

In addition to its involvement in cell death, SIDT2 is also involved in the regulation of cell proliferation. This is important because changes in cell proliferation levels can contribute to the development and progression of many diseases, including cancer.

SIDT2 has also been shown to play a role in the regulation of stem cell proliferation. This is important because stem cells are involved in the development and treatment of many diseases, including cancer. By regulating stem cell proliferation, SIDT2 may play a role in the development and treatment of these diseases.

SIDT2 is also involved in the regulation of the immune system, which is a crucial process that is abnormal and may lead to many diseases, including autoimmune diseases. This is important because the immune system is responsible for protecting the body against foreign invasion, but it can also cause inflammation and damage to the body's tissues when it malfunctions.

In conclusion, SIDT2 is a protein that is involved in the regulation of several cellular processes, including cell death, cell proliferation, and inflammation. Its involvement in these processes makes it a potential drug target for the development of new treatments for a variety of diseases . Further research is needed to fully understand the role of SIDT2 in the regulation of cell death and the development and progression of diseases.

Protein Name: SID1 Transmembrane Family Member 2

Functions: Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity)

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