SHLD1: A Potential Drug Target and Biomarker (G149840)

Target Name: SHLD1

NCBI ID: G149840

SHLD1: A Potential Drug Target and Biomarker

Shieldin complex subunit 1 (SHLD1) is a protein that plays a critical role in the development and maintenance of tissues, particularly the nervous system. It is a member of the shieldin complex, which is a protein complex involved in the regulation of cellular processes such as cell growth, differentiation, and survival. The shieldin complex is composed of several subunits, including SHLD1, which is essential for its proper function.

Recent studies have identified SHLD1 as a potential drug target and biomarker for a variety of diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. This is due to SHLD1's involvement in several cellular processes that are disrupted in these diseases, as well as its unique structure and expression pattern.

One of the main functions of SHLD1 is its role in the regulation of cell growth and differentiation. SHLD1 helps to ensure that cells maintain a proper size and shape, and that they do not undergo rapid growth or uncontrolled division. This is important for the development and maintenance of tissues, as well as for the prevention of cancer.

In addition to its role in cell growth and differentiation, SHLD1 is also involved in the regulation of cell survival. It has been shown to play a role in the regulation of cell survival and apoptosis, which is the process by which cells undergo programmed cell death. This is important for the regulation of cellular aging and the prevention of age-related diseases.

The shieldin complex is also involved in the regulation of cell-cell interactions and tissue architecture. SHLD1 helps to ensure that cells stick to each other and form tissues, and that they do not detach or migrate away from their proper locations. This is important for the development and maintenance of tissues and organs, as well as for the regulation of normal physiological processes.

In conclusion, SHLD1 is a protein that plays a critical role in several cellular processes that are important for the development and maintenance of tissues and organs. Its involvement in cell growth, differentiation, and survival, as well as its unique structure and expression pattern, make it an attractive target for drug development and research into the underlying causes of various diseases. Further studies are needed to fully understand the role of SHLD1 in these processes and to develop effective treatments for SHLD1-related diseases.

Protein Name: Shieldin Complex Subunit 1

Functions: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres

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