SHE: A Protein Target for Small Molecules and Biomarker for Disease

Target Name: SHE

NCBI ID: G126669

SHE: A Protein Target for Small Molecules and Biomarker for Disease

SHE (SH2 domain-containing adapter protein E) is a protein that is expressed in various cell types of the human body, including neurons, liver cells, and blood vessels. It is a member of the SH2 family of proteins, which are known for their role in cell signaling and protein-protein interactions. In this article, we will discuss the potential implications of SHE as a drug target or biomarker, and the research that has been done to study its function in disease.

The SHE protein is composed of 215 amino acid residues and has a calculated molecular mass of 31.1 kDa. It has a single SH2 domain, which is a structural region that is composed of a variable number of amino acids. The SHE domain is responsible for the protein's ability to interact with other proteins, as well as its role in cell signaling.

One of the unique features of the SHE protein is its ability to form a protein-protein interaction (PPI) with other proteins. This interaction is known as a SH- domain interaction and is a common feature of proteins that are involved in signaling pathways. The SHE protein forms PPIs with a variety of proteins, including the protein known as FAK (focal adhesion kinase). These PPIs play a role in the regulation of cell signaling pathways, including the TGF-β pathway.

In addition to its role in cell signaling, the SHE protein is also involved in the regulation of cellular processes such as cell adhesion, migration, and invasion. It has been shown to play a role in the regulation of neural cell migration, and is also involved in the regulation of cancer cell invasion and metastasis.

As a drug target, SHE has the potential to be a target for small molecules that can modulate its function and activity. For example, studies have shown that inhibitors of the SHE protein can block the activity of FAK and other proteins involved in cell signaling pathways. This suggests that SHE may be a useful target for diseases that are characterized by abnormal cellular signaling, such as cancer.

In addition to its potential as a drug target, the SHE protein is also a potential biomarker for a variety of diseases. For example, SHE has been shown to be involved in the regulation of cellular processes that are altered in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. As such, SHE may be a useful biomarker for these diseases, and could be used in the development of new diagnostic tests and therapies.

The study of the SHE protein has also been an important area of research in recent years, as its function and regulation continue to be an active area of study. SHE has been shown to play a role in a variety of cellular processes, including cell signaling, cell adhesion, and migration. In addition, studies have shown that the SHE protein is involved in the regulation of cellular processes that are altered in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

In conclusion, the SHE protein is a complex protein that is involved in a variety of cellular processes and functions. Its unique ability to form PPIs with other proteins makes it a potential drug target, and its role in the regulation of cellular processes makes it a potential biomarker for a variety of diseases. Further research is needed to fully understand the function and regulation of the SHE protein, and its potential as a drug target and biomarker.

Protein Name: Src Homology 2 Domain Containing E

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