SHANK2-AS1: A Potential Drug Target and Biomarker (G100874198)

Target Name: SHANK2-AS1

NCBI ID: G100874198

Other Name(s): SHANK2 antisense RNA 1 (non-protein coding) | SHANK2 antisense RNA 1, transcript variant 2 | SHANK2 antisense RNA 1 | SHANK2-AS1 variant 2

SHANK2-AS1: A Potential Drug Target and Biomarker

SHANK2-AS1, also known as SCL/TAL1, is a non-coding RNA molecule that plays a crucial role in the regulation of cellular processes. It is a key regulator of the T-cell receptor (TCR), which is responsible for cell-mediated immunity. The TCR is a transmembrane protein that is involved in the recognition of foreign antigens and in the generation of T-cells that recognize and respond to these antigens.

SHANK2-AS1 is a protein that is expressed in many different tissues, including the brain, spleen, heart, and kidneys. It is primarily localized to the nuclei of these cells and is involved in the regulation of various cellular processes, including cell growth, apoptosis, and inflammation.

One of the most promising aspects of SHANK2-AS1 is its potential as a drug target. SHANK2-AS1 has been shown to play a role in the regulation of T-cell receptor function, and it is thought to be involved in the development of T-cell exhaustion. This is an important issue because T-cell exhaustion is a hallmark of cancer, and understanding the regulation of T-cell function is crucial for the development of effective cancer treatments.

In addition to its potential as a drug target, SHANK2-AS1 has also been shown to be a potential biomarker. The TCR is a transmembrane protein that is involved in the recognition of foreign antigens, and SHANK2-AS1 is thought to be involved in the regulation of TCR function. This suggests that SHANK2-AS1 may be a useful biomarker for the diagnosis and treatment of T-cell disorders, such as cancer.

One of the challenges in studying SHANK2-AS1 is its complex structure. SHANK2-AS1 is a non-coding RNA molecule, which means that it is not made by the cell and does not have a known primary structure. To study its function, researchers have used a variety of techniques, including RNA sequencing and biochemical assays.

In addition to its potential as a drug target and biomarker, SHANK2-AS1 is also of interest because it is a key regulator of the T-cell receptor. The TCR is a transmembrane protein that is involved in the recognition of foreign antigens and in the generation of T-cells that recognize and respond to these antigens. SHANK2-AS1 is thought to be involved in the regulation of TCR function, which suggests that it may play a key role in the development of immune responses to foreign antigens.

In conclusion, SHANK2-AS1 is a non-coding RNA molecule that is expressed in many different tissues and is involved in the regulation of various cellular processes, including cell growth, apoptosis, and inflammation. Its potential as a drug target and biomarker makes it an important area of research for the development of effective cancer treatments. Further studies are needed to fully understand the function of SHANK2-AS1 and its potential as a drug and biomarker.

Protein Name: SHANK2 Antisense RNA 1

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