SH3BP5L: A Protein Targeted for Drug and Biomarker Development

Target Name: SH3BP5L

NCBI ID: G80851

SH3BP5L: A Protein Targeted for Drug and Biomarker Development

SH3BP5L, also known as SH3BP5L variant 1, is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the SH3BP5 family, which is known for its role in intracellular signaling pathways. In recent years, researchers have become interested in studying SH3BP5L as a potential drug target or biomarker due to its unique biology and the potential it holds for treating various diseases.

The SH3BP5L protein is composed of 151 amino acids and has a calculated molecular mass of 19.9 kDa. It is expressed in a variety of tissues, including the brain, heart, liver, kidney, and pancreas. It is also found in the cytoplasm of cultured cells and in the extracellular matrix of tissues. SH3BP5L is a glycoprotein, which means it consists of a protein that is covalently bound to glucose.

SH3BP5L has been shown to play a role in intracellular signaling pathways. It is a component of the protein complex known as the SH3BP5L-SPOP complex, which is involved in the regulation of cell signaling pathways. This complex is composed of various proteins, including SH3BP5L, SPOP, and TIP60. The SH3BP5L protein is thought to interact with SPOP and TIP60 to regulate the activity of these proteins.

In addition to its role in intracellular signaling pathways, SH3BP5L has also been shown to be involved in the regulation of cellular processes that are important for maintaining tissue health. For example, it has been shown to play a role in the regulation of cell migration and the assembly of tissues. It is also involved in the regulation of cell apoptosis, which is the process by which cells die when they have reached their lifespan.

As a potential drug target, SH3BP5L is of interest because of its unique biology and the potential it holds for treating various diseases. One of the main advantages of SH3BP5L as a drug target is its expression in a variety of tissues, which makes it a potential target for drugs that can affect it in different parts of the body. This can help to reduce the risk of adverse side effects and improve the effectiveness of the treatment.

In addition to its potential as a drug target, SH3BP5L is also of interest as a biomarker. The SH3BP5L protein is expressed in various tissues and can be used as a protein biomarker to diagnose and monitor diseases. For example, it has been shown to be involved in the regulation of inflammation and has been used as a biomarker for various inflammatory diseases, including arthritis and asthma.

In conclusion, SH3BP5L is a protein that has gained significant interest in recent years due to its unique biology and the potential it holds for treating various diseases. As a potential drug target and biomarker, SH3BP5L is of interest for further research into its role in intracellular signaling pathways and its potential as a treatment for various diseases. Further studies are needed to fully understand its biology and potential as a drug target and biomarker.

Protein Name: SH3 Binding Domain Protein 5 Like

Functions: Functions as guanine nucleotide exchange factor (GEF) for RAB11A

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