SFRP4: A Potential Drug Target Or Biomarker for Multiple Diseases

Target Name: SFRP4

NCBI ID: G6424

SFRP4: A Potential Drug Target Or Biomarker for Multiple Diseases

SFRP4 (SFRP4_HUMAN) is a protein that is expressed in various tissues of the human body. It is a member of the Sfrp family, which is known for its role in intracellular signaling pathways. SFRP4 has been identified as a potential drug target or biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

SFRP4 is expressed in a variety of tissues in the human body, including the brain, heart, liver, and pancreas. It is highly expressed in the liver, which is a known hub for drug resistance and metabolism. SFRP4 is also expressed in the blood vessels, which may be a potential target for drug delivery.

SFRP4 is involved in several intracellular signaling pathways that are important for various cellular processes, including cell signaling, cell adhesion, and inflammation. One of the well-studied functions of SFRP4 is its role in the regulation of theNotch signaling pathway. Notch signaling is a critical pathway that regulates cell survival and proliferation, and it is implicated in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

SFRP4 is a key regulator of theNotch signaling pathway in the liver. It is part of a complex that includes several other proteins, including Notch1 and Notch2. SFRP4 functions as a negative regulator of Notch1, which is a transcription factor that plays a role in the regulation of gene expression. SFRP4 helps to prevent Notch1 from activating its downstream targets, which are involved in cell proliferation and survival.

SFRP4 is also involved in the regulation of the Wnt signaling pathway, which is involved in the development and maintenance of tissues in the body. Wnt signaling is a critical pathway that regulates cell growth, differentiation, and patterning, and it is implicated in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

SFRP4 is a key regulator of the Wnt signaling pathway in the liver. It is part of a complex that includes several other proteins, including Wnt1 and Wnt3. SFRP4 functions as a negative regulator of Wnt1, which is a transcription factor that plays a role in the regulation of gene expression. SFRP4 helps to prevent Wnt1 from activating its downstream targets, which are involved in cell growth and survival.

In addition to its role in intracellular signaling pathways, SFRP4 is also involved in the regulation of cellular processes that are important for maintaining tissue homeostasis. SFRP4 is a regulator of the erythropoietin (EP) receptor, which is involved in the production of red blood cells. EP receptor function is important for maintaining tissue homeostasis and is implicated in several diseases, including anemia, thrombosis, and cancer.

SFRP4 is also involved in the regulation of the angiogenesis pathway, which is involved in the formation of new blood vessels. Angiogenesis is important for maintaining tissue repair and regeneration, and it is implicated in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

SFRP4 is a potential drug target or biomarker for several diseases. Its role in the regulation of intracellular signaling pathways, including the Notch and Wnt signaling pathways, makes it a promising target for small molecules that can modulate these pathways. SFRP4 is also involved in the regulation of cellular processes that are important for maintaining tissue homeostasis, including the production of red blood cells and the formation of new blood vessels. Further research is needed to determine the full spectrum of functions of SFRP4 and its potential as a drug target or biomarker.

Protein Name: Secreted Frizzled Related Protein 4

Functions: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927)

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