PLXNB2: A Potential Drug Target for Pregnancy and Health (G23654)

Target Name: PLXNB2

NCBI ID: G23654

PLXNB2: A Potential Drug Target for Pregnancy and Health

PLXNB2 is a protein that is expressed in the human placenta, and it is involved in the development and maintenance of healthy pregnancies. The PLXNB2 gene has been identified as a potential drug target for several diseases, including cancer, neurodegenerative disorders, and infertility.

PLXNB2 is a transmembrane protein that is expressed in the human placenta, meaning that it spans the cell membrane and is associated with the nucleus. It is a member of the T-cell receptor (TCR) family, which is a group of proteins that play a critical role in the immune system.

PLXNB2 is involved in several important processes that are necessary for a healthy pregnancy. For example, it is involved in the development and maintenance of the neural tube, which forms the baby's brain and spinal cord. It also plays a role in the development of the placenta, which is responsible for providing the baby with the necessary nutrients and oxygen.

In addition to its role in pregnancy, PLXNB2 is also involved in the development and maintenance of healthy tissues in the body. For example, it has been shown to be involved in the development of cancer, and it has also been linked to a number of neurodegenerative disorders.

One of the reasons why PLXNB2 has such a strong potential as a drug target is that it is highly conserved across different species. This means that it is likely to have a similar structure and function in different organisms, which makes it a good candidate for drugs that can be used to treat similar conditions.

Another reason why PLXNB2 is a promising drug target is that it is involved in several key processes that are important for human health. For example, it is involved in the development and maintenance of the placenta, which is critical for the health and survival of the baby. It is also involved in the immune system, which is important for protecting the body against infection and disease.

In addition to its potential benefits for human health, PLXNB2 is also a good candidate for a drug because it is relatively easy to produce in the body. This is important because it is often difficult to produce drugs that are both effective and safe for use in humans. By using cell-based assays and other techniques, researchers have been able to produce PLXNB2 in the lab, which allows them to study its properties and potential uses.

Overall, PLXNB2 is a protein that is involved in several important processes that are necessary for human health. As a result, it is a promising drug target for the treatment of a wide range of conditions, including cancer, neurodegenerative disorders, and infertility. Further research is needed to fully understand the role of PLXNB2 in human health and to develop safe and effective drugs that can be used to treat its many effects.

Protein Name: Plexin B2

Functions: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity)

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