Discovering PODN: A Protein Involved in Cellular Processes and Cancer Progression

Target Name: PODN

NCBI ID: G127435

Discovering PODN: A Protein Involved in Cellular Processes and Cancer Progression

PODN (Proteoglycan-Induced DNA Nucleotide Excision) is a protein that is expressed in various cell types, including epithelial, hematopoietic, and neural cells. It is characterized by its ability to induce DNA nucleotide excision in response to proteoglycan (PG) stimulation. PGs are a family of extracellular matrix (ECM) molecules that play a crucial role in cell-cell adhesion, migration, and invasion.

The discovery and characterization of PODN has important implications for our understanding of how PGs regulate cellular processes. PODN has been shown to be involved in various cellular processes, including cell adhesion, migration, and the regulation of gene expression. Its function as a drug target or biomarker is of great interest, as it may provide new avenues for the development of therapeutic interventions.

PODN is a 26-kDa protein that is expressed in a variety of cell types, including epithelial, hematopoietic, and neural cells. It is characterized by its ability to induce DNA nucleotide excision in response to PG stimulation. PGs are a family of extracellular matrix (ECM) molecules that play a crucial role in cell-cell adhesion, migration, and invasion. They are involved in the regulation of many cellular processes, including cell adhesion, migration, and the regulation of gene expression.

PODN has been shown to be involved in various cellular processes, including cell adhesion, migration, and the regulation of gene expression. Its function as a drug target or biomarker is of great interest, as it may provide new avenues for the development of therapeutic interventions.

One of the most significant functions of PODN is its role in cell adhesion. PODN has been shown to be involved in the regulation of cell-cell adhesion by influencing the formation of tight junctions and adherens junctions, which are complex structures that mediate cell-cell communication. tight junctions are a type of cell-cell adhesion that is characterized by the presence of a continuous cytoplasmic bridge between adjacent cells. Adherens junctions, on the other hand, are a type of cell-cell adhesion that is characterized by the presence of a bridge-like structure that connects the cytoskeleton of the two cells.

PODN has been shown to play a crucial role in the regulation of tight junction formation by influencing the activity of the transcription factor, ETV6. ETV6 is a key regulator of tight junction formation and has been shown to play a role in the regulation of PODN expression . Additionally, PODN has been shown to play a role in the regulation of adherens junction formation by influencing the activity of the transcription factor, NUDT3.

In addition to its role in cell adhesion, PODN has also been shown to be involved in the regulation of gene expression. PODN has been shown to play a role in the regulation of gene expression by influencing the activity of the transcription factor, SMAD3. is a key regulator of gene expression and has been shown to play a role in the regulation of PODN expression.

PODN has also been shown to be involved in the regulation of cellular processes that are important for cancer progression. For example, PODN has been shown to play a role in the regulation of the migration of cancer cells by influencing the activity of the transcription factor, ALDH1L1. Additionally, PODN has been shown to play a role in the regulation of the invasion of cancer cells by influencing the activity of the transcription factor, CDK4.

The potential clinical applications of PODN are vast. PODN has been shown to play a role in the regulation of

Protein Name: Podocan

Functions: Negatively regulates cell proliferation and cell migration

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