POLR2D: A Potential Drug Target and Biomarker (G5433)

Target Name: POLR2D

NCBI ID: G5433

POLR2D: A Potential Drug Target and Biomarker

POLR2D is a gene that encodes a protein involved in the repair of DNA damage in cells. The damage caused by various factors such as aging, UV radiation, and genetic mutations can lead to the formation of DNA double-strand breaks, which can lead to the development of diseases such as cancer. The POLR2D protein plays a crucial role in repairing these breaks and maintaining genomic stability.

POLR2D is a double-stranded DNA-binding protein that contains a unique domain called the N-terminal alpha-helix. This domain is known to play a crucial role in the stability and structure of the protein. It is also involved in the formation of DNA double-strand breaks, which are critical for the development of diseases.

POLR2D has been identified as a potential drug target in the field of cancer treatment. Studies have shown that the expression of POLR2D is often increased in cancer cells compared to normal cells. Additionally, the N-terminal alpha-helix domain of POLR2D has been shown to be involved in the development of cancer.

Drugs that target the N-terminal alpha-helix domain of POLR2D have been shown to have potential therapeutic benefits. One such drug is currently in clinical trials for the treatment of breast cancer. These drugs work by inhibiting the activity of the N-terminal alpha-helix domain, which would reduce the formation of DNA double-strand breaks and the development of cancer.

Another potential drug that targets the N-terminal alpha-helix domain of POLR2D is being studied for the treatment of neurodegenerative diseases. The N-terminal alpha-helix domain of POLR2D has been shown to be involved in the formation of neurodegenerate diseases, and drugs that target this domain have been shown to be effective in treating these conditions.

Conclusion

POLR2D is a protein that plays a crucial role in the repair of DNA damage in cells. The N-terminal alpha-helix domain of this protein has been shown to be involved in the formation of DNA double-strand breaks, which are critical for the development of diseases. As a result, POLR2D has been identified as a potential drug target for the treatment of a variety of diseases, including cancer and neurodegenerative diseases.

While further research is needed to fully understand the role of POLR2D in disease development and the potential benefits of drugs that target this protein, it is clear that it has the potential to be a valuable tool in the fight against these devastating conditions.

Protein Name: RNA Polymerase II Subunit D

Functions: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity)

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