POMT2: A Potential Drug Target for Neurodegenerative Diseases

Target Name: POMT2

NCBI ID: G29954

POMT2: A Potential Drug Target for Neurodegenerative Diseases

POMT2 (Promyelocytic leukemia zinc finger 2) is a gene that encodes a protein known as POMT2. POMT2 is a protein that is expressed in various tissues throughout the body, including the brain, heart, and blood cells. It is also known as MDDGB2, which stands for \"middle DNA-binding gene 2\".

The POMT2 gene was first identified in the late 1990s by researchers at the University of California, San Diego. The gene was later named POMT2, and the gene product was named POMT2 protein.

POMT2 is a zinc finger gene, which means that it contains a zinc finger motif. The zinc finger motif is a structural motif that is found in many proteins, and it is associated with protein stability and function.

POMT2 is expressed in many different tissues and cells throughout the body, including the brain, heart, and blood cells. It is also expressed in various organs and tissues, such as the liver, pancreas, and gastrointestinal tract.

One of the functions of POMT2 is to regulate the development and proliferation of cells. It is known to be involved in the regulation of cell proliferation, differentiation, and survival.

POMT2 is also involved in the regulation of cellular processes such as cell adhesion, migration and invasion.

Additionally, POMT2 is also known to be involved in the regulation of the immune response, and in the regulation of inflammation.

POMT2 has also been linked to various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the most promising aspects of POMT2 is its potential as a drug target. Researchers are studying the potential therapeutic uses of POMT2, with a focus on using it to treat neurodegenerative diseases.

One of the main targets of POMT2 is the neurodegenerative disease Alzheimer's disease. Alzheimer's disease is a progressive neurodegenerative disease that is characterized by the accumulation of toxic beta-amyloid proteins in the brain.

POMT2 has been shown to be involved in the production and progression of beta-amyloid proteins, and it is thought to be a potential therapeutic target for Alzheimer's disease.

Another potential therapeutic use of POMT2 is its potential as a treatment for neurodegenerative diseases such as Parkinson's disease and Huntington's disease.

POMT2 has also been studied as a potential therapeutic for autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.

In addition, POMT2 has also been studied as a potential therapeutic for cancer, and it has been shown to have anti-tumor effects in various cancer models.

Overall, POMT2 is a gene that has the potential to be a drug target for a variety of diseases. Further research is needed to fully understand its functions and to develop safe and effective therapies.

Protein Name: Protein O-mannosyltransferase 2

Functions: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129)

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