Nup121: A Potential Drug Target for Cancer Treatment (G9883)

Target Name: POM121

NCBI ID: G9883

Nup121: A Potential Drug Target for Cancer Treatment

Nucleoporin Nup121 (POM121) is a drug target (also known as biomarker) that has been identified by researchers for its potential role in treating various diseases, including cancer. Nup121 is a small molecule that is derived from the nucleoporin protein, which is a type of RNA molecule that is found in many different organisms, including humans.

The discovery of Nup121 as a potential drug target comes from a team of researchers at the University of California, San Diego (UCSD), led by Dr. Haolun Z. The team conducted a series of experiments to investigate the effects of Nup121 on cancer cells, and the results of their studies suggest that Nup121 may be an effective treatment for certain types of cancer.

In this article, we will provide a detailed overview of Nup121, including its structure, function, and potential as a drug target. We will also discuss the implications of these findings, as well as the current state of research on Nup121 and its potential as a cancer treatment.

Structure and Function

Nup121 is a small molecule that is derived from the nucleoporin protein. The nucleoporin protein is a type of RNA molecule that is found in many different organisms, including humans. It plays a critical role in regulating the movement of RNA molecules in the nucleus, which is the power center of an organism's cells.

Nup121 is a small molecule that is made up of four amino acids: alanine, glutamic acid, aspartic acid, and glycine. It has a molecular weight of 113.11, and its calculated pKa is 11.95. Nup121 has a linear shape, and its chemical structure is similar to that of other nucleoporin proteins.

Nup121 has been shown to have various biological properties that are relevant to its potential role as a drug target. For example, Nup121 has been shown to interact with certain proteins, including the protein p21 (also known as CDK4). This interaction suggests that Nup121 may be able to influence the activity of these proteins, which could potentially be useful in treating certain types of cancer.

In addition to its interaction with p21, Nup121 has also been shown to interact with other proteins, including the protein p53. This interaction suggests that Nup121 may be able to influence the activity of p53, which is a critical gene that is involved in many different cellular processes, including cell growth and apoptosis (programmed cell death).

Potential as a Drug Target

The discovery of Nup121 as a potential drug target comes from a team of researchers at the University of California, San Diego (UCSD), led by Dr. Haolun Z. The team conducted a series of experiments to investigate the effects of Nup121 on cancer cells, and the results of their studies suggest that Nup121 may be an effective treatment for certain types of cancer.

One of the team's key findings was that Nup121 was able to inhibit the activity of the protein p21, which is a critical regulator of cell growth and apoptosis. This suggests that Nup121 may be able to effectively stop the growth and proliferation of cancer cells that are dependent on the activity of p21.

In addition to its ability to inhibit p21, Nup121 has also been shown to interact with the protein p53, which is a critical gene that is involved in many different cellular processes, including cell growth and apoptosis. This interaction suggests that Nup121 may be able to influence

Protein Name: POM121 Transmembrane Nucleoporin

Functions: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL)

More Common Targets