POLR3K: Key Component of RNA Polymerase III Enzyme (G51728)

Target Name: POLR3K

NCBI ID: G51728

POLR3K: Key Component of RNA Polymerase III Enzyme

POLR3K, also known as RNA polymerase III subunit CII, is a protein that plays a crucial role in the process of RNA synthesis. It is a subunit of the RNA polymerase III enzyme, which is responsible for transcribing DNA into RNA. POLR3K is a key component of this enzyme and is essential for its function.

POLR3K is a 21 kDa protein that consists of 156 amino acids. It has a molecular weight of 21 kDa and a calculated pI of 6.9. It is expressed in all cell types and is highly conserved across different species.

POLR3K functions as a subunit of the RNA polymerase III enzyme, which is responsible for transcribing DNA into RNA. The RNA polymerase III enzyme is a complex protein that consists of multiple subunits, including the alpha, beta, and gamma subunits. The alpha subunit is the most abundant and is responsible for the initiation of the transcription process. The beta and gamma subunits are involved in the process of proofreading, which ensures the accuracy of the RNA transcript.

POLR3K is a key component of the RNA polymerase III enzyme, as it plays a critical role in the process of transcription. It is essential for the initiation and progression of the transcription process, as well as the regulation of gene expression.

POLR3K is involved in the process of RNA synthesis by participating in the initiation of the RNA polymerase III reaction. It functions as a subunit of the enzyme and is located at the active site of the alpha subunit. It is involved in the formation of the active site, which is the binding site for the DNA template.

POLR3K is also involved in the regulation of gene expression by participating in the process of RNA degradation. It is a potent negative regulator and can inhibit the activity of RNA polymerase III, which is responsible for transcribing DNA into RNA. This inhibition allows for the regulation of gene expression and the expression of specific genes.

POLR3K is a potential drug target and can be used as a biomarker for the diagnosis and treatment of various diseases. The inhibition of the activity of POLR3K has been shown to be effective in treating certain diseases, such as cancer. In addition, the over-expression of POLR3K has been shown to be associated with the development of certain diseases, such as neurodegenerative diseases.

In conclusion, POLR3K is a protein that plays a crucial role in the process of RNA synthesis and is a key component of the RNA polymerase III enzyme. It is essential for the initiation and progression of the transcription process and for the regulation of gene expression. The inhibition of the activity of POLR3K has been shown to be effective in treating certain diseases and can be used as a biomarker for the diagnosis and treatment of these diseases. Further research is needed to fully understand the role of POLR3K in disease progression and to develop effective treatments.

Protein Name: RNA Polymerase III Subunit K

Functions: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170). Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:12391170, PubMed:30584594). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses (PubMed:19631370, PubMed:19609254). Acts as nuclear and cytosolic DNA sensor involved in innate immune response (PubMed:19631370, PubMed:19609254). Can sense non-self dsDNA that serves as template for transcription into dsRNA (PubMed:19631370, PubMed:19609254). The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19631370, PubMed:19609254)

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