POLR1A: A Potential Drug Target and Biomarker (G25885)

Target Name: POLR1A

NCBI ID: G25885

POLR1A: A Potential Drug Target and Biomarker

Introduction

POLR1A (poly (A) rRNA-1A) is a non-coding RNA molecule that plays a crucial role in the function of RNA polymerase II (RNA-II), which is responsible for generating double-stranded RNA molecules in the cytosol of eukaryotic cells. POLR1A is a key component of the RNA-II complex and is essential for the initiation of DNA replication in the cytosol. The function of POLR1A has been extensively studied, and its role in various cellular processes has been well-described.

Drug Target Potential

POLR1A has been identified as a potential drug target due to its involvement in the regulation of gene expression and its role in the development of various diseases. Several studies have shown that alterations in the levels of POLR1A have been associated with the development of various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the key mechanisms through which POLR1A is involved in the regulation of gene expression is its role in the control of splicing, a process that is essential for the production of functional RNA molecules. POLR1A has been shown to interact with splicing factors, which are proteins that work to ensure the accuracy and efficiency of gene expression. By modulating the activity of these splicing factors, POLR1A has been shown to play a role in the regulation of gene expression and the development of various diseases.

Another mechanism through which POLR1A is involved in the regulation of gene expression is its role in the regulation of RNA stability. POLR1A has been shown to play a role in the degradation of non-coding RNAs, which are short RNAs that are not functional by themselves but can be involved in the regulation of gene expression. This function of POLR1A is important for the regulation of gene expression and the development of various diseases.

Biomarker Potential

POLR1A has also been identified as a potential biomarker for several diseases. The levels of POLR1A have been shown to be altered in a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders. These changes in the levels of POLR1A have been associated with the development of various diseases, and may be used as biomarkers for these diseases.

One of the key applications of POLR1A as a biomarker is its ability to be targeted with small molecules. This is because the levels of POLR1A are well-characterized, and the potential targets for small molecules have been identified. These targets include splicing factors, RNA stability factors, and other proteins that are involved in the regulation of gene expression.

Conclusion

POLR1A is a non-coding RNA molecule that plays a crucial role in the function of RNA polymerase II and the regulation of gene expression. Its role in the regulation of gene expression and the development of various diseases makes it an attractive target for small molecules. Further research is needed to fully understand the function of POLR1A and its potential as a biomarker for various diseases.

Protein Name: RNA Polymerase I Subunit A

Functions: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity)

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