POLR1E: A Non-Code RNA Molecule Regulating Gene Expression (G64425)

Target Name: POLR1E

NCBI ID: G64425

POLR1E: A Non-Code RNA Molecule Regulating Gene Expression

POLR1E (Polymerase (RNA) I associated factor 1) is a non-coding RNA molecule that plays a critical role in the regulation of gene expression in eukaryotic cells. It is a key factor in the polymerase I (RNA polymerase I) complex, which is responsible for the production of RNA transcripts from DNA templates.

POLR1E is a protein that is expressed in various tissues and cells, including the brain, heart, liver, and muscle. It is primarily localized to the cytoplasm of the cells and is involved in the regulation of gene expression.

POLR1E functions as a negative regulator of gene expression by interacting with the polymerase I complex. It does this by interacting with the active site of the polymerase I complex, where the substrate DNA is being copied. This interaction between POLR1E and the polymerase I complex allows for the inhibition of gene expression by the complex.

POLR1E is also involved in the regulation of post-transcriptional gene regulation (PTGR), which is the process by which gene expression is modified after the initial transcription of the RNA molecule. This includes the regulation of RNA stability, localization to specific cellular compartments, and interactions with protein factors that can affect gene expression.

POLR1E is a potential drug target because of its involvement in the regulation of gene expression. By targeting the function of POLR1E, researchers may be able to develop new treatments for various diseases that are caused by the over-expression or under-expression of specific genes.

In addition to its potential as a drug target, POLR1E is also a potential biomarker for certain diseases. The over-expression or under-expression of specific genes can be used as a diagnostic tool for diseases such as cancer, neurodegenerative diseases, and genetic disorders.

Overall, the function of POLR1E as a non-coding RNA molecule that plays a critical role in the regulation of gene expression makes it an attractive target for research and treatment of various diseases.

Protein Name: RNA Polymerase I Subunit E

Functions: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (PubMed:24207024). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024)

More Common Targets