KIAA0958: Role in Cell Signaling and Disease (G23275)

Target Name: POFUT2

NCBI ID: G23275

KIAA0958: Role in Cell Signaling and Disease

Protoplasmic Organic Folding (POF) is a protein that plays a crucial role in cell signaling and division. It is a protein that folds into its specific shape, which is necessary for it to function properly. POFs are involved in many different processes in the cell , including the cell cycle, cell signaling, and DNA replication.

One of the proteins that fold into POFs is known as KIAA0958. KIAA0958 is a protein that is found in many different cell types, including muscle cells, nerve cells, and epithelial cells. It is involved in the regulation of the cell cycle, and it has been shown to play a role in the development and progression of many different diseases.

Diseases and Conditions

One of the diseases that POFs are involved in is cancer. Cancer is a disease that is characterized by the formation of tumors, which are abnormal cells that can grow out of control. The cell cycle is a key aspect of the development and progression of cancer , and POFs are involved in this process.

KIAA0958 has been shown to promote the growth and survival of cancer cells. Studies have shown that KIAA0958 can inhibit the death of cancer cells, and that it can also inhibit the formation of blood vessels that can supply these cells with the oxygen and nutrients they need to grow.

Another disease that POFs are involved in is neurodegenerative disorders. These are conditions that are characterized by the progressive loss of brain cells, and they can include diseases such as Alzheimer's and Parkinson's. POFs are involved in the regulation of the cell cycle and the formation of neurotransmitters, which are important for the function of nerve cells.

KIAA0958 has been shown to contribute to the development and progression of neurodegenerative disorders. Studies have shown that KIAA0958 can cause neurotransmitters to become misfolded, which can lead to the loss of brain cells and the development of neurodegenerative disorders.

KIAA0958 is also involved in the regulation of the immune system. POFs are involved in the regulation of the cell cycle, and they are important for the development and activation of immune cells.

KIAA0958 has been shown to contribute to the development of autoimmune diseases. Studies have shown that KIAA0958 can cause immune cells to become misfolded, which can lead to the development of autoimmune diseases.

Molecular Mechanisms

The exact mechanism by which KIAA0958 promotes the growth and survival of cancer cells is not fully understood. However, it is thought to work by inhibiting the death of cancer cells and promoting the formation of blood vessels that can supply these cells with the oxygen and nutrients they need to grow.

One of the possible mechanisms by which KIAA0958 promotes the growth and survival of cancer cells is by inhibiting the production of reactive oxygen species (ROS). ROS are free radicals that can damage cells and contribute to the development and progression of cancer.

KIAA0958 may also work by inhibiting the activity of genes that are involved in cell growth and division. This can lead to the inhibition of the growth and survival of cancer cells.

KIAA0958 may also contribute to the development and progression of neurodegenerative disorders by inhibiting the production of neurotransmitters. Neurotransmitters are important for the function of nerve cells, and their production is

Continuous folding of POFs is a critical process that helps maintain cellular homeostasis, and it is also involved in many cellular processes, such as cell division, apoptosis, and inflammation. The misfolding of POFs has been implicated in various diseases, including cancer, neurodegenerative disorders , and autoimmune diseases. Therefore, the study of POFs and their misfolding is an important area of 鈥嬧?媟esearch with potential implications for the development of new therapeutic approaches.

Protein Name: Protein O-fucosyltransferase 2

Functions: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:22588082). O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable) (PubMed:17395588). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (PubMed:17395589, PubMed:17395588). The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity)

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