Polynucleotide 3'-phosphatase: A Key Enzyme in DNA Replication and Repair

Target Name: PNKP

NCBI ID: G11284

Polynucleotide 3'-phosphatase: A Key Enzyme in DNA Replication and Repair

Polynucleotide 3'-phosphatase (PNKP) is a protein that plays a crucial role in the regulation of DNA replication and repair. It is a key enzyme in the DNA damage response, which is a critical process that helps ensure that the genetic material of the cell is preserved in the event of DNA damage. PNKP is also involved in the regulation of gene expression and cell growth, and it is a potential drug target in the treatment of a variety of diseases.

PNKP is a protein that is expressed in a variety of tissues and cells, including the nucleus, the mitochondria, and the endoplasmic reticulum. It is a 25kDa protein that consists of two subunits that are held together by a disulfide bond. PNKP has a catalytic active site that is located at the base of the phosphate group, and it has a distinct preference for specific nucleotides as substrates.

PNKP is involved in the regulation of DNA replication and repair. It is a key enzyme in the DNA damage response, which is a critical process that helps ensure that the genetic material of the cell is preserved in the event of DNA damage. During DNA replication, PNKP plays a crucial role in the formation of a double helix. It is essential for the recruitment of the enzyme DNA polymerase to the site of the replication break, and it is involved in the regulation of the movement of the DNA polymerase along the double helix.

PNKP is also involved in the regulation of gene expression and cell growth. It is a regulator of the cell cycle, and it is involved in the G1/S transition, which is a critical step in the cell cycle that is associated with the growth and development of cells. PNKP is also involved in the regulation of cell adhesion and the development of tissues.

PNKP is a potential drug target in the treatment of a variety of diseases. For example, it is a known biomarker for several types of cancer, including breast cancer, lung cancer, and colorectal cancer. It is also a potential target for diseases that are caused by disruptions in the DNA damage response, such as neurodegenerative diseases and autoimmune diseases.

In addition to its role in the regulation of DNA replication and repair, PNKP is also involved in the regulation of cellular processes that are important for the survival of cells. It is a regulator of cell survival and has been shown to play a role in the regulation of cell death. It is also involved in the regulation of cell signaling pathways, and it is a potential target for drugs that are used to treat a variety of diseases.

Overall, PNKP is a protein that is involved in a variety of important cellular processes that are critical for the survival and growth of cells. It is a potential drug target for the treatment of a variety of diseases and is a promising area of research for the development of new treatments.

Protein Name: Polynucleotide Kinase 3'-phosphatase

Functions: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193)

More Common Targets