FLRT3: A Potential Drug Target Or Biomarker for Neurodegenerative Disorders

Target Name: FLRT3

NCBI ID: G23767

FLRT3: A Potential Drug Target Or Biomarker for Neurodegenerative Disorders

FLRT3 (Fluoride-Responsive Transmembrane Protein 3) is a protein that is expressed in various tissues of the human body, including the brain, pancreas, and muscle. It is involved in a variety of physiological processes in the body, including regulation of ion channels , neurotransmitter signaling, and cell signaling pathways.

Recent studies have suggested that FLRT3 may have potential as a drug target or biomarker for various diseases, including Alzheimer's disease, Parkinson's disease, and neurodegenerative disorders. This is because the dysfunction of FLRT3 has been implicated in the development and progression of these conditions.

One of the key mechanisms by which FLRT3 is involved in these diseases is its role in modulating the expression of genes that are involved in neurotransmission and cellular signaling. For example, studies have shown that FLRT3 can interact with the neurotransmitter receptor PSD-90, which is involved in the release of neurotransmitters such as dopamine and serotonin. This interaction may play a role in the regulation of mood, emotion, and other neurological processes.

Additionally, FLRT3 has been shown to be involved in the regulation of ion channels that are involved in neurotransmission. For example, FLRT3 has been shown to interact with the ion channel protein Nav1. This interaction may be involved in the regulation of neurotransmitter release and the maintenance of the resting membrane potential of neurons.

The dysfunction of FLRT3 has also been implicated in the development of neurodegenerative disorders. For example, studies have shown that mice that have been genetically modified to lack FLRT3 have reduced neurotransmitter release and increased sensitivity to neurotoxins, suggesting that FLRT3 may play a role in the development of neurodegenerative disorders.

In addition to its involvement in neurotransmission and cellular signaling pathways, FLRT3 has also been shown to be involved in the regulation of cell signaling pathways. For example, studies have shown that FLRT3 can interact with the protein p120, which is involved in the regulation of cell signaling pathways. This interaction may play a role in the regulation of cellular processes such as cell growth, apoptosis, and angiogenesis.

Overall, the dysfunction of FLRT3 has been implicated in the development and progression of a variety of neurodegenerative disorders. Therefore, FLRT3 may be a promising drug target or biomarker for these conditions. Further research is needed to fully understand the role of FLRT3 in these diseases and to develop effective treatments.

Protein Name: Fibronectin Leucine Rich Transmembrane Protein 3

Functions: Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity)

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