FMNL2: A Potential Drug Target and Biomarker (G114793)

Target Name: FMNL2

NCBI ID: G114793

FMNL2: A Potential Drug Target and Biomarker

Formin homology 2 (FMNL2) is a protein that plays a critical role in the regulation of cell growth and division. It is a member of the FN1 family, which includes several similar proteins that share a conserved domain that is involved in the formation of cilia and flagellum (fur and flagellum) in eukaryotic cells. The FMNL2 protein is unique, however, in that it contains a second distinct domain that is involved in the regulation of actin filament organization and dynamics.

The FMNL2 protein is expressed in many different tissues and cells in the body, including the brain, muscle, heart, and blood vessels. It is highly conserved, with a calculated identity of 97% between the human and mouse protein sequences. This conservation suggests that FMNL2 may be a useful drug target or biomarker, as it is likely to be highly conserved in other organisms and to be involved in a wide range of biological processes.

FMNL2 has been shown to be involved in the regulation of actin filament organization and dynamics. It plays a role in the assembly and disassembly of actin filaments, as well as the regulation of the stability and dynamics of these filaments. This is important for many different cellular processes, including cell division, migration, and intracellular transport.

In addition to its role in actin filament regulation, FMNL2 is also involved in the regulation of cell adhesion and migration. It has been shown to be involved in the formation of tight junctions, which are a type of cell-cell adhesion that helps to maintain tissue structure and prevent excessive fluid leakage. It is also involved in the regulation of cell migration, as it has been shown to play a role in the migration of neurons in the brain.

FMNL2 has also been shown to be involved in the regulation of cell survival and proliferation. It has been shown to play a role in the regulation of cell cycle progression, as well as the regulation of apoptosis (programmed cell death). This is important for many different cellular processes, including the regulation of cell growth and differentiation, and the regulation of cell survival and proliferation.

In conclusion, FMNL2 is a protein that is involved in a wide range of cellular processes that are important for the maintenance of cellular structure and function. As such, it is a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of FMNL2 in cellular processes and to develop effective treatments based on this understanding.

Protein Name: Formin Like 2

Functions: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics

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