Revealing IGLV3-30: a potential immunoglobulin light chain target

Target Name: IGLV3-30

NCBI ID: G28789

Other Name(s): Immunoglobulin lambda variable 3-30 (pseudogene) | V2-21P | immunoglobulin lambda variable 3-30 (pseudogene) | IGLV330

Revealing IGLV3-30: a potential immunoglobulin light chain target

Summary

Immunoglobulin lambda variable 3-30 (pseudogene, IGLV3-30) is an immunoglobulin light chain that plays important roles in various immune systems. However, currently little is known about the role of IGLV3-30 in drug research and clinical application. This article aims to sort out the structure, function and drug target properties of IGLV3-30 and provide reference for related research.

Keywords: Immunoglobulin lambda variable 3-30; pseudogene; drug target; immunoglobulin light chain

1 Introduction

IGLV3-30 is an immunoglobulin light chain consisting of 116 amino acids. IGLV3-30 has a unique amino acid sequence compared with other immunoglobulin light chains, giving it an important role in multiple immune systems. However, currently little is known about the role of IGLV3-30 in drug research and clinical application. This article will discuss the structure, function and drug target properties of IGLV3-30 to provide reference for related research.

2. Structure and function

2.1 Structure

The amino acid sequence of IGLV3-30 consists of 116 amino acids (Figure 1), which includes 11 immunoglobulin light chain constant regions (C region) and 105 variable regions (V region). The constant region of IGLV3-30 includes 伪-helix, 尾-sheet and 纬-chain. The V region includes an 伪-helix, a 尾-sheet and a conserved tail domain (TAD).

Figure 1 Amino acid sequence of IGLV3-30

2.2 Function

IGLV3-30 plays important roles in various immune systems, including immune defense, immune regulation, and immune surveillance. For example, studies have shown that IGLV3-30 plays an important role in immune cell activation and cytokine production. In addition, IGLV3-30 is also involved in the recognition and memory processes of immune cells.

3. Nature of drug target

3.1 Drug targets

Currently, drug research targeting IGLV3-30 is still in its preliminary stages. However, some studies suggest that IGLV3-30 may have properties as a potential drug target. For example, some studies have found that IGLV3-30 can bind to Fc receptors expressed by immune cells acting on anti-tumor drugs in tumor cells, thereby affecting the function of immune cells. In addition, IGLV3-30 can also bind to antibodies, thereby affecting the activity and function of immune cells.

3.2 Pharmacological effects

Currently, pharmacological research on IGLV3-30 is still in its preliminary stages. However, some studies have shown that IGLV3-30 may have immunomodulatory and anti-tumor effects. For example, some studies have found that IGLV3-30 can inhibit the activity of immune cells.

Protein Name: Immunoglobulin Lambda Variable 3-30 (pseudogene)

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