Target Name: IKZF3
NCBI ID: G22806
Other Name(s): Zinc finger protein Aiolos (isoform 6) | Ikaros family zinc finger protein 3 | Aiolos | IKZF3 variant 2 | Aio-del2 | IKAROS family zinc finger 3 | AIOLOS | Zinc finger protein, subfamily 1A, 3 (Aiolos) | zinc finger protein, subfamily 1A, 3 (Aiolos) | IKZF3_HUMAN | IMD84 | IKZF3 variant 1 | IKAROS family zinc finger 3 (Aiolos), transcript variant 2 | Aio-1 | Zinc finger protein Aiolos (isoform 2) | zinc finger DNA binding protein Aiolos | IKAROS family zinc finger 3, transcript variant 2 | AIO | ZNFN1A3 | Zinc finger protein Aiolos (isoform 1) | IKAROS family zinc finger 3, transcript variant 1 | Zinc finger protein Aiolos

IKZF3: A Zinc Finger Protein and Potential Drug Target

Introduction

The zinc finger protein Aiolos (ISOFORM 6) is a key regulator of gene expression and has been implicated in various cellular processes. It is a transmembrane protein that contains a nucleotide-binding oligomerization domain (NBD), a conserved protein-coding region, and a C-terminal extension that includes a zinc finger domain. Zinc finger proteins are a family of non-coding RNAs that play a crucial role in post-transcriptional gene regulation by binding to specific cis-elements in the 3'-untranslated regions of target genes.

IKZF3, also known as Aiolos (ISOFORM 6), is a zinc finger protein that is expressed in various tissues and has been implicated in various cellular processes. It is a key regulator of gene expression, cell signaling, and DNA replication. IKZF3 has been shown to play a crucial role in the regulation of cell proliferation, differentiation, and apoptosis.

Potential Drug Targets

The zinc finger domain of IKZF3 is a known drug target. Zinc finger proteins have been shown to be involved in various cellular processes, including cell signaling, DNA replication, and apoptosis. Therefore, targeting IKZF3 may be a promising strategy for the development of new drugs.

IKZF3 has been shown to play a role in cell proliferation and has been linked to the regulation of cell cycle progression. It has been shown that IKZF3 inhibits the G1-S transition, which is a critical step in the cell cycle and is associated with the growth and development of cancer. Therefore, targeting IKZF3 may be a promising strategy for the development of anti-cancer drugs.

IKZF3 has also been shown to play a role in the regulation of cell apoptosis. Apoptosis is a natural mechanism of cell death that is regulated by various factors, including IKZF3. Therefore, targeting IKZF3 may be a promising strategy for the development of anti-apoptotic drugs.

IKZF3 has been shown to play a role in the regulation of DNA replication. DNA replication is a critical process that is essential for the growth and development of all cells. Therefore, targeting IKZF3 may be a promising strategy for the development of drugs that can inhibit DNA replication in cancer cells.

Conclusion

In conclusion, IKZF3 is a zinc finger protein that has been shown to play a crucial role in various cellular processes. It has been implicated in the regulation of cell proliferation, apoptosis, and DNA replication. Therefore, targeting IKZF3 may be a promising strategy for the development of new drugs. Further research is needed to fully understand the role of IKZF3 in cellular processes and to develop effective new treatments.

Protein Name: IKAROS Family Zinc Finger 3

Functions: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner

More Common Targets

IKZF4 | IKZF5 | IL-1 Receptor | IL-10 Receptor | IL-11 receptor | IL-12 receptor | IL-13 receptor | IL-15 receptor | IL-17 Receptor | IL-2 receptor | IL-20 receptor | IL-22 Receptor | IL-23 receptor complex | IL-27 receptor | IL-3 receptor | IL-31 Receptor | IL-4 receptor | IL-5 receptor | IL-6 receptor | IL10 | IL10RA | IL10RB | IL10RB-DT | IL11 | IL11RA | IL12A | IL12A-AS1 | IL12B | IL12RB1 | IL12RB2 | IL13 | IL13RA1 | IL13RA2 | IL15 | IL15RA | IL16 | IL17A | IL17B | IL17C | IL17D | IL17F | IL17RA | IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5