IL-36A: Unlocking Its Potential Therapeutic Applications (G27179)

Target Name: IL36A

NCBI ID: G27179

IL-36A: Unlocking Its Potential Therapeutic Applications

The IL-36A molecule, also known as IL-1F6 (FIL-1-epsilon) or interleukin-36A, is a protein that plays a crucial role in the immune system. It is a member of the interleukin family, which includes other proteins such as IL-1, IL-2, and IL-12, which are involved in the regulation of inflammation and immune responses. IL-36A is expressed in a variety of tissues and cells in the body, including the immune system, and has been shown to play a key role in the regulation of inflammation, tissue repair, and cell survival.

One of the key functions of IL-36A is its ability to stimulate the production of immune cells, such as T cells and NK cells, which are important for maintaining the immune system's response to infections and diseases. IL-36A also plays a role in the regulation of inflammation by promoting the production of pro-inflammatory cytokines, such as TNF-alpha, IL-1尾, and IL-6. These cytokines are important for the recruitment of immune cells to the site of an infection or injury, and for the regulation of tissue repair and inflammation.

In addition to its role in immune function, IL-36A has also been shown to have a variety of potential therapeutic applications. For example, it has been shown to be a potential drug target for a variety of diseases, including cancer, autoimmune diseases, and chronic obstructive pulmonary disease (COPD). In addition, IL-36A has also been shown to be a potential biomarker for a variety of diseases, including cancer and cardiovascular disease.

One of the key challenges in studying IL-36A is its complex structure and function. IL-36A is a large protein with 184 amino acid residues, and it contains multiple domains, including an N-terminus, a T-terminus, and a middle body that contains a variety of conserved features, such as a leucine-rich repeat and a calcineurin-like domain. These features make it difficult to study the full function of IL-36A, and much of its structure and function remain unresolved.

In recent years, researchers have made significant progress in the study of IL-36A. One of the main achievements has been the identification of a variety of cellular and biological processes that are regulated by IL-36A. For example, studies have shown that IL-36A can promote the development and differentiation of immune cells, and that it can also play a role in the regulation of cell survival and inflammation. In addition, research has also shown that IL-36A can be involved in the regulation of various biological processes, including cell proliferation, apoptosis, and metabolism.

Despite these advances, much of the function of IL-36A remains unexplored, and many questions about its role in the immune system and its potential therapeutic applications remain unanswered. For example, it is not yet clear exactly how IL-36A promotes the development and differentiation of immune cells, or how it interacts with other immune molecules. In addition, there is a need for further research to determine the full range of biological processes that are regulated by IL-36A, and to explore its potential as a drug target or biomarker.

In conclusion, IL-36A is a complex and highly functionally diverse protein that plays a crucial role in the immune system. Its ability to stimulate the production of immune cells and regulate inflammation makes it an attractive target for therapeutic applications. Further research is needed to fully understand the function of IL-36A and its potential as a drug

Protein Name: Interleukin 36 Alpha

Functions: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes up-regulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by up-regulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in pro-inflammatory effects in the lung

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