IL-6ST: A Potential Drug Target Or Biomarker (G3572)

Target Name: IL6ST

NCBI ID: G3572

IL-6ST: A Potential Drug Target Or Biomarker

IL-6ST, also known as Interleukin-6 receptor subunit beta, is a protein that is expressed in various tissues throughout the body. It is a key component of the interleukin-6 receptor, which is a protein that is involved in the regulation of immune and inflammatory responses. IL-6ST has been shown to play a crucial role in the regulation of these processes, and is therefore considered a potential drug target or biomarker.

IL-6ST is a cytoplasmic protein that is expressed in a variety of tissues, including blood cells, epithelial cells, and tissues of the central nervous system. It is a 21-kDa protein that consists of two extracellular domains and an intracellular domain. The intracellular domain is responsible for the interaction with the interleukin-6 receptor, which is a protein that is expressed in various tissues throughout the body.

The interleukin-6 receptor is a protein that is involved in the regulation of immune and inflammatory responses. It is a type of cytokine receptor, which is a protein that is involved in the signaling of various cellular processes. The interleukin-6 receptor is composed of a cytoplasmic part and cell membrane part. The cytoplasmic portion consists of an N-terminal 伪-helix, a central 尾-sheet and a C-terminal domain. The cell membrane portion consists of an N-terminal 伪-helix, a central 尾-sheet and a C-terminal domain.

IL-6ST is a key component of the interleukin-6 receptor, and it is involved in the regulation of various cellular processes. One of the most well-known functions of IL-6ST is its role in the regulation of immune responses. IL- 6ST has been shown to play a crucial role in the regulation of T cell development and activation. It has also been shown to play a role in the regulation of the cytokine response to infection.

In addition to its role in immune responses, IL-6ST is also involved in the regulation of various other cellular processes. For example, it has been shown to play a role in the regulation of cell growth, cell differentiation, and cell survival. It is also involved in the regulation of cell-cell interactions and in the regulation of the cytoskeleton.

IL-6ST is also considered a potential biomarker for certain diseases. For example, it has been shown to be elevated in the blood of individuals with certain types of cancer, such as lung cancer and breast cancer. individuals with certain autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.

Due to its involvement in the regulation of various cellular processes, IL-6ST is considered a promising drug target or biomarker. Studies have shown that the intervention of IL-6ST can have a variety of therapeutic effects. For example, it has been shown to have anti-inflammatory effects and to inhibit the growth of cancer cells.

In conclusion, IL-6ST is a cytoplasmic protein that is involved in the regulation of various cellular processes. It is a key component of the interleukin-6 receptor and has been shown to play a crucial role in the regulation of immune and inflammatory responses. Its potential as a drug target or biomarker makes it an attractive target for further research.

Protein Name: Interleukin 6 Cytokine Family Signal Transducer

Functions: Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed:19386761). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity)

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