IMPDH1: Unlocking The Potential of A Key Enzyme (G3614)

Target Name: IMPDH1

NCBI ID: G3614

Other Name(s): IMPDH1 variant 1 | IMP (inosine 5'-monophosphate) dehydrogenase 1 | inosine monophosphate dehydrogenase 1 | Inosine monophosphate dehydrogenase 1, transcript variant 5 | IMP (inosine monophosphate) de

IMPDH1: Unlocking The Potential of A Key Enzyme

IMPDH1 (IMPure Productive Domain-1) is a protein that is expressed in various tissues throughout the body, including the liver, pancreas, and intestine. It is a key player in the idiopathic non-alcoholic steatohepatitis (NASH), a common form of liver disease that is characterized by inflammation and damage to the liver cells.

IMPDH1 is a member of the IMP family, which includes a variety of enzymes that are involved in the production of purines, which are substances that are excreted by the body after being synthesized from nucleotides. Purines are important for maintaining cellular health and are also involved in the treatment of many diseases, including NASH.

IMPDH1 is expressed in the liver and pancreas, and it plays a role in the metabolism of uracils, which are byproducts of DNA synthesis that can be harmful to the liver if not properly metabolized. In NASH, uracils can accumulate in the liver and contribute to the inflammation and damage that is seen in this disease. By participating in the metabolism of uracils, IMPDH1 may help to protect the liver from the harmful effects of these byproducts.

In addition to its role in NASH, IMPDH1 is also thought to be involved in the development and progression of many other diseases. For example, it has been shown to be involved in the development of fibrosis, a type of cancer that can lead to the formation of tumors. It has also been linked to the development of cardiovascular disease and other conditions that are important health concerns for humans.

Despite the potential importance of IMPDH1 in many diseases, it is not yet a drug target or biomarker. This is because while there is evidence to suggest that IMPDH1 may be involved in a number of important biological processes, it is not yet clear how it can be targeted or used to diagnose or treat specific diseases. Further research is needed to fully understand the role of IMPDH1 in disease and to develop ways to use it more effectively for the benefit of healthcare.

In conclusion, IMPDH1 is a protein that is expressed in various tissues throughout the body that is involved in the metabolism of uracils and may be involved in the development and progression of many diseases. Further research is needed to fully understand its role and to develop ways to use it more effectively for the benefit of healthcare.

Protein Name: Inosine Monophosphate Dehydrogenase 1

Functions: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors

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