Target Name: IL18RAP
NCBI ID: G8807
Other Name(s): CDw218b | IL-18 receptor beta | Interleukin-18 receptor accessory protein (isoform 1) | interleukin-18 receptor beta | cluster of differentiation w218b | Interleukin-18 receptor accessory protein-like | ACPL | IL18RAP variant 1 | Interleukin 18 receptor accessory protein, transcript variant 1 | AcPL | Interleukin-18 receptor beta | I18RA_HUMAN | IL-1R accessory protein-like | IL-1R7 | IL-18RAcP | interleukin 18 receptor accessory protein | IL-18 receptor accessory protein | IL-1RAcPL | Accessory protein-like | interleukin-1 receptor 7 | CD218b | IL18RB | IL-18R-beta | Interleukin-1 receptor 7 | Interleukin-18 receptor accessory protein | IL-1R-7 | CD218 antigen-like family member B | IL-18Rbeta

IL18RAP: A Protein Involved in Multiple Physiological Processes

IL18RAP (Interleukin-18 receptor antagonist-related protein) is a protein that is expressed in various tissues throughout the body, including the lungs, heart, kidneys, and intestines. It is a member of the IL18 receptor family, which is a group of cytokines that play a crucial role in the regulation of immune and inflammatory responses.

IL18RAP is a 21 kDa protein that is expressed in a variety of tissues, including the lungs, heart, kidneys, and intestines. It is a member of the IL18 receptor family, which is a group of cytokines that play a crucial role in the regulation of immune and inflammatory responses. The IL18 receptor family includes several different proteins, including IL18, IL18R1, IL18R2, and IL18R3. These proteins are involved in the regulation of various physiological processes, including immune responses, inflammation, and tissue repair.

IL18RAP is involved in the regulation of several different biological processes. For example, it has been shown to be involved in the regulation of inflammation in the lungs. Studies have shown that IL18RAP can inhibit the activity of pro-inflammatory cytokines, such as TNF- alpha and IL-18, which are involved in the regulation of inflammation. This suggests that IL18RAP may have potential as a therapeutic agent for the treatment of respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD).

In addition to its involvement in inflammation, IL18RAP is also involved in the regulation of cell-cell signaling. For example, it has been shown to be involved in the regulation of stem cell proliferation and the differentiation of immune cells. This suggests that IL18RAP may have potential as a therapeutic agent for the treatment of diseases that involve stem cell dysfunction, such as cancer.

IL18RAP is also involved in the regulation of the immune response. For example, it has been shown to be involved in the regulation of the activation and proliferation of natural killer cells, which are a type of immune cell that play a crucial role in the regulation of cancer cells. This suggests that IL18RAP may have potential as a therapeutic agent for the treatment of cancer.

In conclusion, IL18RAP is a protein that is expressed in various tissues throughout the body and is involved in the regulation of several different biological processes, including inflammation, cell-cell signaling, and the immune response. Its potential as a therapeutic agent for the treatment of various diseases makes it an attractive target for further research. Further studies are needed to fully understand the role of IL18RAP in the regulation of various physiological processes and its potential as a therapeutic agent.

Protein Name: Interleukin 18 Receptor Accessory Protein

Functions: Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable)

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IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK | ILKAP | ILRUN | ILVBL | Imidazoline I2 receptor (I2) | Imidazoline I3 receptor (I3) | Imidazoline receptor | IMMP1L | IMMP2L | IMMT | IMMTP1 | Immunoglobulin A | Immunoglobulin E (IgE) | Immunoglobulin G | Immunoglobulin M | Immunoglobulin-Like Domain Containing Receptor | Immunoproteasome | IMP3 | IMP4 | IMPA1 | IMPA1P1 | IMPA2 | IMPACT | IMPDH1 | IMPDH1P10 | IMPDH1P6 | IMPDH2 | IMPG1 | IMPG2 | INA | INAFM1 | INAFM2