IL3 as A Regulator of Mast Cell Growth and Function (G3562)

Target Name: IL3

NCBI ID: G3562

IL3 as A Regulator of Mast Cell Growth and Function

IL3 (Interleukin-3) is a cytokine that plays a crucial role in the regulation of immune responses and cell growth. It is a cytokine that is produced by various types of immune cells, including T cells, natural killer cells, and B cells. It is also a potent stimulator of cell growth and division, and has been shown to have a wide range of biological effects.

One of the key functions of IL3 is its ability to stimulate the growth and proliferation of various types of cells, including mast cells. Mast cells are a type of immune cell that are responsible for producing and releasing histamine, which is a chemical that causes itching and inflammation when reacted to an allergen. Mast cells are also involved in the regulation of allergic responses and are a potential therapeutic target for a variety of conditions, including allergies, eczema, and asthma.

IL3 has been shown to be a powerful regulator of mast cell growth and function. It is able to stimulate the growth and proliferation of mast cells in a variety of ways, including through direct interaction with its cell surface receptors and through the production of various signaling molecules that can promote cell growth.

One of the key mechanisms by which IL3 promotes mast cell growth is through its ability to induce the production of histamine. Histamine is a potent stimulator of cell growth and division, and is able to induce the production of various signaling molecules that can promote cell proliferation. IL3 has been shown to induce the production of histamine by a variety of cell types, including mast cells, and this increase in histamine production is thought to play a key role in the regulation of mast cell growth and function.

Another mechanism by which IL3 promotes mast cell growth is through its ability to stimulate the production of cell surface molecules that are involved in cell adhesion and migration. Mast cells are highly adhesive cells that are able to migrate through the body and interact with other cells in order to participate in immune responses. IL3 has been shown to stimulate the production of cell surface molecules that are involved in cell adhesion and migration, including integrins and cadherins. This increase in cell surface molecules allows mast cells to migrate more easily through the body and interact with other cells.

In addition to its ability to stimulate cell growth and division, IL3 is also involved in the regulation of allergic responses and has been shown to play a key role in the development of allergies. Allergies are characterized by an overreaction of the immune system to a particular allergen, which results in the production of antibodies and the release of histamine from mast cells. IL3 has been shown to play a key role in the regulation of this process, as it is able to stimulate the production of histamine and promote the growth and division of mast cells.

IL3 is also involved in the regulation of pain and inflammation. It is able to stimulate the production of pro-inflammatory molecules, such as TNF-alpha and IL-8, which can contribute to the development of pain and inflammation. This is thought to be one of the ways in which IL3 promotes mast cell growth and function.

In conclusion, IL3 is a potent regulator of mast cell growth and function, and has a wide range of biological effects. Its ability to stimulate the production of histamine, cell surface molecules involved in cell adhesion and migration, and pro-inflammatory molecules is thought to be key to its role in the regulation of mast cell function and the development of allergies, pain, and inflammation. As a potential drug target and biomarker, IL3 is a promising area of research for the treatment of a variety of conditions.

Protein Name: Interleukin 3

Functions: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:2556442). Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated (PubMed:10779277, PubMed:32889153). In addition, plays an important role in neural cell proliferation and survival (PubMed:23226269). Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation (PubMed:12816992). Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (PubMed:29374162). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (PubMed:27862234)

More Common Targets