Target Name: IL12B
NCBI ID: G3593
Other Name(s): IL12, subunit p40 | IL12B_HUMAN | Interleukin-12 beta chain | interleukin-12 beta chain | Cytotoxic lymphocyte maturation factor 40 kDa subunit | IL-12 subunit p40 | interleukin 12B | Interleukin-12 subunit beta | p40 | cytotoxic lymphocyte maturation factor 40 kDa subunit | CLMF2 | NKSF2 | interleukin 12, p40 | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | IL-12B | CLMF p40 | CLMF | Natural killer cell stimulatory factor-2 | IMD29 | Interleukin 12B | IMD28 | natural killer cell stimulatory factor, 40 kD subunit | NKSF | NK cell stimulatory factor chain 2

The Subunit P40: A Key Regulator of IL-12 Signaling

The interleukin-12 (IL-12) signaling pathway is a critical factor in the regulation of immune and inflammatory responses. IL-12 is a cytokine that plays a crucial role in the development and maintenance of effector T cells, which are a vital part of the immune system. The IL-12 signaling pathway is also involved in the regulation of natural killer cells, which are an important part of the immune system that helps to eliminate damaged or infected cells.

One of the key proteins involved in the IL-12 signaling pathway is the subunit p40. The subunit p40 is a key regulator of the IL-12 signaling pathway, and it is involved in the regulation of multiple cellular processes, including cell survival, apoptosis, and inflammation.

The subunit p40 is a protein that is expressed in many different tissues and cells, including T cells, natural killer cells, and macrophages. It is a key regulator of the IL-12 signaling pathway, and it is involved in the development and maintenance of these cell types.

One of the key functions of the subunit p40 is its role in cell survival. The subunit p40 is involved in the regulation of cell apoptosis, which is the process by which cells die when they are no longer needed. In T cells, the subunit p40 helps to regulate apoptosis by promoting the production of a protein called Bax, which is involved in the regulation of cell death.

Another function of the subunit p40 is its role in inflammation. The subunit p40 is involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-alpha and IL-18. These cytokines play a crucial role in the regulation of immune responses and are involved in the development of inflammatory diseases.

The subunit p40 is also involved in the regulation of cell proliferation. It is a key regulator of theIL-12 signaling pathway, which is involved in the regulation of cell proliferation. The subunit p40 helps to regulate the production of IL-12, which is a cytokine that plays a crucial role in the regulation of cell proliferation.

In addition to its role in cell survival, apoptosis, and inflammation, the subunit p40 is also involved in the regulation of many other cellular processes. For example, it is involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues. It is also involved in the regulation of cell migration, which is the process by which cells move from one location to another in the body.

The subunit p40 is a protein that is expressed in many different tissues and cells. It is a key regulator of the IL-12 signaling pathway, and it is involved in the regulation of multiple cellular processes, including cell survival, apoptosis, and inflammation. Further research is needed to better understand the role of the subunit p40 in the regulation of immune and inflammatory responses.

Protein Name: Interleukin 12B

Functions: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC

More Common Targets

IL12RB1 | IL12RB2 | IL13 | IL13RA1 | IL13RA2 | IL15 | IL15RA | IL16 | IL17A | IL17B | IL17C | IL17D | IL17F | IL17RA | IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK | ILKAP | ILRUN | ILVBL | Imidazoline I2 receptor (I2) | Imidazoline I3 receptor (I3) | Imidazoline receptor | IMMP1L | IMMP2L