Target Name: IL15RA
NCBI ID: G3601
Other Name(s): interleukin 15 receptor subunit alpha | sIL-15 receptor subunit alpha | IL-15 receptor subunit alpha | Interleukin-15 receptor subunit alpha | soluble form of IL-15RA | sIL-15RA | sIL-15R-alpha | I15RA_HUMAN | IL-15RA | IL15RA variant 1 | IL-15R-alpha | sIL-15RA_(HUMAN) | Soluble interleukin-15 receptor subunit alpha | Interleukin 15 receptor subunit alpha, transcript variant 1 | CD215 | interleukin 15 receptor, alpha | Interleukin-15 receptor subunit alpha (isoform 1)

IL-15R伪: A Potential Drug Target and Biomarker

Interleukin 15 (IL-15) is a cytokine that plays a crucial role in the regulation of immune and inflammatory responses. The IL-15 receptor subunit alpha (IL-15RA) is a key component of the IL-15 receptor, which is a protein that is expressed in various tissues throughout the body. The IL-15RA protein has been identified as a potential drug target and biomarker due to its involvement in the regulation of inflammation, immune cell function, and metabolism.

The IL-15RA protein is a cytoplasmic protein that is expressed in various tissues, including the liver, spleen, and lymphoid organs. It is a member of the IL-1 family of cytokines, which includes proteins such as IL-1, IL-2, and IL-12. The IL-15RA protein is involved in the regulation of cellular processes such as cell growth, apoptosis, and inflammation.

One of the key functions of the IL-15RA protein is its role in the regulation of immune cell function. The IL-15RA protein is involved in the development and function of natural killer (NK) cells, which are a type of immune cell that play a critical role in the regulation of cancer and other diseases. NK cells are able to recognize and destroy infected or abnormal cells in the body, making them an important part of the immune system.

In addition to its role in immune cell function, the IL-15RA protein is also involved in the regulation of metabolism. The IL-15RA protein is involved in the metabolism of fatty acids, which are an essential source of energy for the body. The IL-15RA protein is able to regulate the rate at which fatty acids are broken down and the amount of fatty acids that are available for use as energy.

The potential drug target status of the IL-15RA protein is due to its involvement in the regulation of inflammation. The IL-15RA protein is involved in the regulation of the inflammatory response, as it is able to inhibit the production of pro-inflammatory cytokines. This has the potential to make the IL-15RA protein an attractive target for drugs that are designed to alleviate inflammation and promote health.

The IL-15RA protein is also a potential biomarker for a variety of diseases. The expression of the IL-15RA protein is often increased in diseases such as cancer, obesity, and diabetes. This makes it an potential target for drugs that are designed to reduce the expression of the IL-15RA protein in these diseases.

In conclusion, the IL-15RA protein is a potential drug target and biomarker due to its involvement in the regulation of immune and metabolic processes. The IL-15RA protein is able to regulate the development and function of natural killer cells, influence the metabolism of fatty acids, and participate in the regulation of the inflammatory response. Further research is needed to fully understand the potential clinical applications of the IL-15RA protein, including its potential as a drug target and biomarker.

Protein Name: Interleukin 15 Receptor Subunit Alpha

Functions: High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910)

More Common Targets

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